β-Alanine CAS:107-95-9 White crystalline powder
| Catalog Number | XD90324 |
| Product Name | β-Alanine |
| CAS | 107-95-9 |
| Molecular Formula | C3H7NO2 |
| Molecular Weight | 89.09 |
| Storage Details | Ambient |
| Harmonised Tariff Code | 29224920 |
Chigadzirwa Specification
| Chitarisiko | White crystalline powder |
| Assay | 99% |
Chirwere chisiri-doro chine mafuta echiropa (NAFLD) ine huwandu hwakawanda hwezvirwere kubva kune yakapfava steatosis inoratidzwa nekusagadzikana kwekuchengetedza lipids mukati memasero echiropa kusvika kune steatohepatitis (NASH) ichiratidza kuunganidzwa kwemafuta, kuzvimba, kuputika uye kuora kwehepatocytes, uye fibrosis.Pakupedzisira, steatohepatitis inogona kukonzera chiropa cirrhosis uye hepatocellular carcinoma.Muchidzidzo ichi takaongorora mhando nhatu dzakasiyana dzembeva, A/J, C57BL/6J, uye PWD/PhJ, dzinoratidza madhigirii akasiyana e steatohepatitis paanopihwa 3,5-diethoxycarbonyl. -1,4-dihydrocollidine (DDC) ine kudya.RNA-Seq gene expression analysis, protein analysis uye metabolic profiling yakashandiswa kuratidza zvakasiyana-siyana majini/maprotein uye kukanganiswa kwematabolite mazinga embeva chiropa samples pane DDC-kurapa.Kuongororwa kwenzira kwakaratidza kuchinjwa kwe arachidonic acid (AA) uye S-adenosylmethionine (SAMe) metabolism pane dzimwe nzira.Kuti unzwisise shanduko yemetabolism yearachidonic acid metabolism muchiedza chechirwere kutaura profiles kinetic modhi yeiyi nzira yakagadziridzwa uye yakagadziridzwa zvinoenderana nemazinga emetabolite.Zvadaro, muenzaniso wacho wakashandiswa kudzidza musilico zvinokonzerwa nemishonga inogona kutariswa kune steatohepatitis.Takaona AA/eicosanoid metabolism seyakanyanya kuvhiringidza muDDC-induced mice vachishandisa musanganiswa wekuedza uye musilico nzira.Kuongorora kwedu kweAA / eicosanoid metabolic nzira inoratidza kuti 5-hydroxyeicosatetraenoic acid (5-HETE), 15-hydroxyeicosatetraenoic acid (15-HETE) uye prostaglandin D2 (PGD2) inovhiringidzwa muDDC mice.Isu tinoenderera mberi tichiratidza kuti modhi ine simba inogona kushandiswa kufembera yemhando yekuchinja kwemetabolism yakavakirwa pane transcriptomics data mune inoenderana nechirwere.Uyezve, SAMe metabolism yakaonekwa seiri kuvhiringika nekuda kwekurapwa kweDDC.Majini akati wandei pamwe nemamwe metabolites emu module iyi anoratidza misiyano pakati peA/J neC57BL/6J kune rumwe rutivi uye PWD/PhJ kune rumwe rutivi.
