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1-(3-Carboxypyrid-2-yl) -2-phenyl-4-methyl-piperazine, inozivikanwawo seCPPMP, ikemikari yemakemikari ine chimiro chakaoma chine maitiro akasiyana-siyana mumunda wemakemikari emishonga.Imwe inogona kushandiswa. yeCPPMP iri mukurapa kweurological kusagadzikana.Kuvapo kweboka recarboxypyridyl kunoratidza kugona kwayo kwekudyidzana neiyo chaiyo neuronal receptors mukati mepakati tsinga system.Kutarisa aya ma receptors kunogona kuenzanisa neurotransmission, inogona kutungamira kumhedzisiro yekurapa mumamiriro akaita sekuora mwoyo, kusagadzikana, kana neurodegenerative kusagadzikana.Kuwedzera tsvakurudzo kunodiwa kuti uongorore kupindirana kwakananga kwekugamuchira uye nzira yekuita kweCPPMP kuitira kuti iwedzere kukwanisa kwayo sechirwere chekurapa kwehutano hwehutano hwepfungwa.CPPMP's piperazine core structure inoratidzawo kukwanisa kwayo sechinhu chinotungamira chekugadzirwa kwemishonga mitsva.Mishonga yemakemikari inogona kushandura zvikamu zvakasiyana zvechimiro chayo kuti iwedzere zvimiro zvayo zvemishonga kana kunanga nzira dzebiological.Nokugadzirisa maitiro eCPPMP, vatsvakurudzi vanogona kugadzira zvigadzirwa nekuvandudzwa kwekusarudza, potency, uye kuchengetedzwa kwemaitiro, zvichiita kuti vave vakakodzera vakakodzera kumishonga inotarisana nezvirwere zvakasiyana-siyana.Uyezve, CPPMP's phenyl uye methyl mapoka anopa hydrophobic properties, iyo inogona kubatsira mukugadzira mishonga inogona kuyambuka. maseru membranes uye kuwana intracellular zvinangwa.Ichi chiitiko chinogona kukwidziridzwa kugadzira mishonga yemanovel inonyatso tarisa intracellular enzymes kana nzira, ichipa mikana yekurapa kupindira muzvirwere zvakaita sekenza kana metabolic disorders.Kuwedzera, iyo yakasarudzika maitiro eCPPMP inobvumira iyo inogona kukura yeprodrugs kana dhizaini nzira dzekuendesa zvinodhaka. .Nekugadzirisa boka rayo recarboxypyridyl, musanganiswa unogona kugadzirwa kuti uwedzere kugadzikana kana kushomeka muchetura muchimiro chayo, uku uchinyatso kuendesa iyo inoshanda zvinodhaka moiety kune inodiwa saiti yekuita.Kugadziriswa kwakadaro kunogona kuwedzera bioavailability uye kurapa kwehutano hwekomboni.Inofanira kuonekwa kuti kushandiswa kweCPPMP mune izvi zvingave zvikumbiro ndeyekufungidzira uye zvingada tsvakurudzo yakakosha uye kubudirira kusati kwashandiswa.Uyezve, kushandiswa kwese kweCPPMP kwaizoda kutevedzera zvakatemerwa kuchengetedza mapuroteni uye nhungamiro kuti ive nechokwadi chekubata kwakakodzera uye kuderedza njodzi.Pakupedzisira, 1-(3-Carboxypyrid-2-yl) -2-phenyl-4-methyl-piperazine, kana CPPMP. , inobata chivimbiso chekushandiswa kwakasiyana-siyana mumakemikari emishonga.Chimiro chayo chakaomarara chinopa mikana yekuvandudzwa kwemanoveli ekurapa majekiseni ehutano hwetsinga, pamwe nemishonga inonangana nezvirwere zvakasiyana.Nekuwedzera kutsvagisa nekugadzirisa, CPPMP ine mukana wekuita zvakakosha kumunda wemishonga nekuvandudza mhedzisiro yevarwere.