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1-(3-Hydroxymethylpyridin-2-yl) -4-methyl-2-phenylpiperazine ikemikari ine mikana yakawanda yakawanda yekushandiswa mumakemikari emishonga uye kukura kwemishonga.Kumwe kushandiswa kwechikamu ichi kuri mumunda wemakemikari emishonga. , kunyanya mukuwanikwa kwezvinodhaka.Kuvepo kweboka rehydroxymethylpyridinyl kunoratidza kusangana kungangove nekwakanangana nebiological tarisiro, senge ma enzymes kana receptors.Mishonga yemakemikari inogona kukwidziridza chimiro chekomboni iyi kuti iwedzere hukama hwayo uye kusarudza kune inodiwa biological zvinangwa.Nokugadzirisa mapenyl uye piperazine moieties, vatsvakurudzi vanogona kugadzirisa maitiro emakemikari emukomboni uye pharmacokinetics, izvo zvinogona kutungamirira kuhutano hwakanaka hwemishonga uye kuderedza zvisingadiwi migumisiro. -methyl-2-phenylpiperazine iri mumunda we neuropharmacology.Mamiriro emukomboni uyu anoratidza kusangana kungangoitika nema receptors mukati mepakati tsinga sisitimu, izvo zvinogona kutungamira kumhedzisiro yekurapa mukusagadzikana kwetsinga.Semuenzaniso, inogona kuongororwa semumiriri wekugadzirisa neurotransmission mumamiriro ezvinhu sekufunganya, kushushikana, kana schizophrenia.Vatsvakurudzi vanogona kuongorora maitiro ekomboni uye kuita zvidzidzo zvekiriniki uye zvekiriniki kuti vaone kugona kwayo marapirwo.Uyezve, maumbirwo ekomboni iyi anogona kuita kuti ive yakakodzera kushandiswa kwekutumira zvinodhaka.Yayo hydrophobic phenyl uye methyl mapoka anoratidza mukana wekuyambuka lipid membranes, zvichiita kuti inange intracellular enzymes kana nzira.Ichi chivakwa chakanakira kugadzira mishonga inoda kupinda mumasero uye kuita mhedzisiro yavo pane chaiyo intracellular tarisiro.Nekugadzirisa chimiro chemukomboni, makemikari emishonga anogona kuwedzera bioavailability, kuvandudza kugadzikana kwayo, uye kugadzira nzira dzinoshanda dzekuunza zvinodhaka.Zvakakosha kuziva kuti kushandiswa kwe1-(3-Hydroxymethylpyridin-2-yl) -4-methyl-2 -phenylpiperazine mune izvi zvingangoita zvikumbiro zvinoda kusimba preclinical uye kuongororwa kwekiriniki kuti ive nechokwadi chekuchengetedza, kushanda, uye dosi yakakodzera.Zvakawanda zvemishonga uye toxicological zvidzidzo zvinodiwa kuti unzwisise mhedzisiro yayo pane dzakasiyana masisitimu ebhayoloji uye kuona chero mhedzisiro inogona kuipa. zvinogona kushandiswa mumakemikari emishonga uye kugadzirwa kwezvinodhaka.Inobata chivimbiso chekugadzirwa kwemishonga mitsva, kunyanya munzvimbo dze neuropharmacology uye kuendesa zvinodhaka.Kumwe kutsvagurudza kunodiwa kuti uongorore kudyidzana kwayo chaiko, maitiro echiito, uye kugona kwekurapa, kugadzira nzira yezvinogoneka mukurapa kwezvirwere zvakasiyana uye kusagadzikana.