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(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone, inozivikanwawo seCF12, ikemikari ine mashandisirwo akasiyana-siyana mukutsvakurudza kwemishonga uye synthesis.Kumwe kwekutanga kushandiswa kweCF12 kuri pabasa rayo sechivakwa chinochinjika. kana yepakati pakubatanidzwa kwezvimwe zvakaoma organic komisheni.CF12 ine mapoka anoshanda senge chloro uye fluoro substituents, anogona kushandiswa kuunza mamwe mapoka anodiwa kana magadzirirwo ezvimiro.Izvi zvinobvumira vemakemikari kuti vagadzirise zvinhu zvekomboni uye kuwedzera maitiro ayo emishonga kune mamwe maapplication.CF12 yakaratidza kugona mukugadzirwa kwevanoda zvinodhaka kunzvimbo dzakasiyana siyana dzekurapa.Semuenzaniso, kuvapo kwe chloro uye fluoro substituents muCF12 kunogona kuwedzera lipophilicity yekomboni, iyo inogona kuwedzera kugona kwayo kupinda mubiological membranes uye kunatsiridza kutorwa kwezvinodhaka.Iyi pfuma inonyanya kudiwa mukugadzirwa kwemishonga inopihwa nemuromo.Kuwedzera, CF12's structural features inoita kuti ive mumiriri anonakidza wekuongorora kugona kwayo seanorwisa utachiona.Iko musanganiswa wekomboni yehalogen substituents yakaratidzwa kuratidza yakakura-spectrum antimicrobial chiitiko ichipokana nemhando dzakasiyana dzebhakitiriya nefungi.Izvi zvinovhura mikana yekuti CF12 iongororwe pakugadzirwa kwemishonga inorwisa mabhakitiriya kana mishonga inorwisa fungal. Uyezve, CF12 yakawanikwa iine zvimwe zviitiko zvebhayoloji zvinoita kuti ive yakakodzera kune mamwe marapirwo.Zvidzidzo zvakaratidza kuti CF12 inoratidza akakosha anti-inflammatory properties, zvichiita kuti ive yakakosha pakurapwa kwezvirwere zvinoratidzirwa nekuzvimba, senge autoimmune disorders kana chronic inflammatory conditions.Nepo CF12 ichiratidza vimbiso munzvimbo idzi dzakasiyana-siyana, zvakakosha kuziva kuti tsvakiridzo nekusimudzira zvinodikanwa kuti unzwisise zvizere kugona kwayo semumiriri wezvinodhaka.Zvakawanda zvidzidzo zvepreclinical, zvinosanganisira in vitro uye in vivo bvunzo, zvinodiwa kuti uongorore kushanda kweCF12, pharmacokinetic zvimiro, uye chengetedzo chimiro.Uyezve, optimization yeCF12's kemikari chimiro uye kuongorora kwekuita kwayo kunopesana nezvinangwa zvechirwere zvinodiwa kuti uvhure kugona kwayo kwekurapa.Muchidimbu, (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone (CF12) ikomboni iyo ine chivimbiso chekutsvaga kwemishonga uye synthesis.Kuita kwayo kwakasiyana-siyana sechivakwa chekuvaka kunobvumira kugadzirwa kwezvakaoma organic komisheni, nepo hunhu hwayo hwemishonga senge lipophilicity uye antimicrobial chiitiko chinoita kuti ive mukana wekuvandudza zvinodhaka munzvimbo dzakadai semishonga inorwisa mabhakitiriya, antifungals, uye anti-inflammatory agents.Nekudaro, tsvakiridzo yakakura ichiri kudikanwa kuti uongorore zvizere kugona kwayo kwekurapa uye kuona kugona kwayo semumiriri wezvinodhaka.