2'-Deoxythymidine Cas: 50-89-5
| Catalog Number | XD90582 |
| Product Name | 2'-Deoxythymidine |
| CAS | 50-89-5 |
| Molecular Formula | C10H14N2O5 |
| Molecular Weight | 242.23 |
| Storage Details | Ambient |
| Harmonised Tariff Code | 29349990 |
Chigadzirwa Specification
| Chitarisiko | Hupfu hwakachena kusvika kuchena |
| Assay | 99% |
| Kurasika paKuomesa | <0.5% |
| Residue paIgnition | <0.3% |
| Specific optical rotation | +17.5 - +19.5 |
Isu takambosangana nemaitiro ekudzora umo dihydrotestosterone (DHT) yakashandisa inhibitory mhedzisiro paparathyroid hormone-inoenderana protein (PTHrP) gene kudzoreredzwa kuburikidza neestrogen receptor (ER) α, asi kwete iyo androgen receptor (AR), mukenza yemazamu MCF-7 masero. .Pano, isu takaongorora kana iyo aberrant ligand-nuclear receptor (NR) kupindirana kuripo mukenza yeprostate LNCaP masero.Kutanga, takasimbisa kuti masero eLNCaP anoratidza huwandu hwakawanda hweAR pamazinga asingakoshi eERα/β kana progesterone receptor.Zvose kudzvinyirirwa kwePTHrP uye kushandiswa kweprostate-specific antigen genes zvakaonekwa mushure mekuzvimirira kwekutonga kwe17β-estradiol (E2), DHT, kana R5020.Zvichienderana nepfungwa yekuti LNCaP AR yakarasikirwa nehunhu hwayo nekuda kwekuchinja (Thr-Ala877), kuyedza ne siRNA yakanangana neNR yakaratidza kuti iyo AR yakatonga basa remurevereri weyakagovaniswa-inoenderana nehomoni regulation, iyo yaingogara yakabatana. ine nuclear translocatio n yeiyi mutant AR.Microarray yekuongorora gene regulation neDHT, E2, kana R5020 yakaburitsa kuti inopfuura hafu yemajini kuzasi kweAR (Thr-Ala877) akapindirana mumaseru eLNCaP.Zvekunyanya kufarira, takaona kuti iyo AR (wild-type [wt]) uye AR (Thr-Ala877) vaive nebasa rakaenzana mukudyidzana kweE2-AR.Fluorescence microscopy miedzo yakaratidza kuti ese EGFP-AR (wt) uye EGFP-AR (Thr-Ala877) aingove akaiswa mukati meiyo nucleus mushure meE2 kana DHT kurapwa.Uyezve, mutori wenhau assay akaburitsa kuti mamwe mamwe maseru egomarara airatidza kusaina E2-AR (wt) yakafanana neiyo mumasero eLNCaP.Isu pano tinonyora kuvepo kwekudyidzana kwakabatikana pakati pewt AR neE2 mune mamwe mahormone-sensitive cancer maseru.
