3-Hydroxy-4,5-bis (hydroxymethyl) -2-methylpyridine Cas: 65-23-6 White powder
| Catalog Number | XD90442 |
| Product Name | 3-Hydroxy-4,5-bis (hydroxymethyl) -2-methylpyridine |
| CAS | 65-23-6 |
| Molecular Formula | C8H11NO3 |
| Molecular Weight | 169.18 |
| Storage Details | Ambient |
| Harmonised Tariff Code | 29362500 |
Chigadzirwa Specification
| Chitarisiko | Upfu chena |
| Assay | >99% |
| Density | Same kuchengetedza nguva |
| Residue pa innition | <0.5% |
| Identification | Positive reaction |
| Kurasika paKuomesa | <0.5% |
| Acidity | 2.6 |
Kuchinja kuviri mu cystathionine beta-synthase (CBS) gene yakawanikwa muhama mbiri dzechiJapan dzine pyridoxine isingapindure homocystinuria yaive neakasiyana methionine mazinga muropa ravo panguva yekuzvarwa.Varwere vese vari vaviri vaive mukomboni heterozygotes yeaviri mutant alleles: mumwe aive neA-to-G shanduko panucleotide 194 (A194 G) yakakonzera kutsiva histidine-to-arginine pachinzvimbo 65 cheprotein (H65R), nepo imwe yaive ne G-ku-A shanduko pa nucleotide 346 (G346A) iyo yakaguma nekugadzirisa glycine-to-arginine panzvimbo ye116 yeprotein (G116R).Iwo mapuroteni maviri anoshanduka akaratidzirwa zvakasiyana muEscherichia coli, uye akashaya zvachose kuita kwekuita.Kunyangwe iwo akafanana genotypes uye anenge akaenzana mapuroteni ekudya, mukoma nemunin'ina ava vakaratidza mazinga akasiyana eropa methionine panguva yekuzvarwa, zvichiratidza kuti mwero wemethionine muropa unotarwa kwete nekukanganisika kweiyo CBS gene uye mapuroteni ekudya, asiwo ne basa remamwe ma enzymes anobatanidzwa mumethionine uye homocysteine metabolism, kunyanya panguva yekuzvarwa.Naizvozvo, vana vachangozvarwa vane njodzi yakakura vane vanun'una vane homocystinuria, kunyangwe chiyero chemethionine muropa ravo chakajairika mukuongororwa kweneonatal mass, inofanirwa kuteverwa uye kuongororwa nekuongororwa kwekuita kwe enzyme kana kuongororwa kwemajini kuitira kuti kurapwa kugone kurapwa. yakatanga nokukurumidza sezvinobvira kudzivirira kukura kwekliniki zviratidzo.Pamusoro pezvo, nzira nyowani, inotarisisa yekuongorora kuwanda kwekushomeka kweCBS muvacheche inofanirwa kugadzirwa.
