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(3aR,7aR)-4-(benzo[d]isothiazol-3-yl)octahydrospiro[isoindole-2,1-piperazin]-2-ium4-methylbenzenesulfonate, inonziwo mukomboni BISO, ikemikari ine chimiro chakasiyana chinokweretesa kune zvakawanda zvingango shandiswa mumunda wekemesitiri yemishonga uye kukura kwezvinodhaka.Kumwe kushandiswa kweBISO kunogona kurapa zvirwere zvetsinga.Kuvepo kwebenzo [d] isothiazol-3-yl moiety muchimiro chayo kunoratidza kuti BISO inogona kunge iine kudyidzana nedzimwe neurotransmitter masisitimu muuropi, senge glutamate kana GABAergic masisitimu.Aya ma neurotransmitter masisitimu anosanganisirwa mumatambudziko mazhinji etsinga senge pfari, kufunganya, uye kusagadzikana kwepfungwa.Vatsvakurudzi vaigona kuongorora zvinogona kuitwa neBISO kugadzirisa masisitimu aya uye kugadzira maajenti matsva ekurapa mamiriro etsinga. Pamusoro pazvo, BISO's spiro[isoindole-2,1-piperazin] core structure ine mukana wekushandiswa mukugadzirwa kwemishonga inonangana nemhando dzakasiyana siyana. biological zvinangwa.Chimiro chayo chetatu-dimensional uye kuvapo kwemapoka anoshanda anogona kupindirana nema receptors chaiwo kana ma enzymes, zvichibvumira kugadzirwa kwemishonga inosarudzwa uye ine simba.Vatsvakurudzi vanogona kukwidziridza iyi structural motif kuti vagadzire mamorekuru madiki anonangana nezvinogamuchirika zvinosanganisirwa muzvirwere zvakasiyana-siyana, zvakaita sekenza, kusagadzikana kwemoyo, kana zvirwere zvinotapukira.Zvakare, BISO's spirocyclic structure uye inochajiswa ammonium boka inoita kuti ive mumiriri angangove mumiriri wehurongwa hwekuunza zvinodhaka.Kuvapo kweboka rinopomerwa kunobvumira kuumbwa kweionic complexes nemamolekemu asina kunaka, akadai se nucleic acids kana mapuroteni.Macomplexes aya anogona kufambisa zvakanangwa kuendeswa kwebioactive molecules mumaseru chaiwo kana matishu, zvichiita kuti kurapa kushande uku zvichideredza systemic side effects.Zvakakosha kuziva kuti zvingangoitwa zveBISO ndezvekufungidzira uye zvinoda kumwe kutsvagisa nekuvandudzwa.Chimiro chayo chakasiyana chinopa mikana kune vezvemishonga yezvemishonga kuti vaongorore maitiro ayo ezvemishonga uye nekugadzirisa kukwanisa kwayo kuwanikwa kwezvinodhaka.Sezvinoita chero musanganiswa wemakemikari, kushandiswa kweBISO kunofanirwa kutevedzera zvakatemerwa zvekuchengetedza mapuroteni uye nhungamiro.Vatsvakurudzi vanofanira kuchenjerera panguva yekugadzirwa kwayo, kubata, uye kuchengetedza kuchengetedza uye kuderedza njodzi.Pakupedzisira, (3aR,7aR) -4- (benzo [d] isothiazol-3-yl) octahydrospiro[isoindole-2,1-piperazin. ]-2-ium4-methylbenzenesulfonate, kana BISO, ine vimbiso yekushandiswa kwakasiyana-siyana mumakemikari ekurapa uye kugadzira zvinodhaka.Chimiro chayo chakasiyana chinopa mikana yekuwanikwa kwevatsva vekurapa vamiririri, inonangwa yekuendesa zvinodhaka masisitimu, uye modulation ye neurotransmitter masisitimu.Nekudaro, kutsvagisa kwakadzama kunodiwa kuti ujekese zvizere kugona kwayo uye nekugonesa kushandiswa kwayo mumunda wemishonga.