Products

Acetoxy Empagliflozin, inozivikanwawo se empagliflozin acetate, imhando yakagadziridzwa yeantidiabetic drug empagliflozin.Empagliflozin ndeyekirasi yemishonga inozivikanwa se sodium-glucose co-transporter 2 (SGLT2) inhibitors, iyo inonyanya kushandiswa pakutarisira rudzi rwechipiri chirwere cheshuga mellitus.Nekudzivisa puroteni iyi, (3R,4S,5R,6R) -3,4,5-tris(triMethylsilyloxy) -6-((triMethylsilyloxy)Methyl)tetrahydro-2H-pyran-2-one ikemikari yakaoma kunzwisisa ine zita remakemikari refu.Inowira pasi pekirasi yetriMethylsilyloxy pyranones, iyo inoshandiswa zvakanyanya mumhando dzakasiyana dzesainzi nemaindasitiri.Kumwe kwekushandiswa kwakakosha kwe(3R,4S,5R,6R) -3,4,5-tris(triMethylsilyloxy) -6-( (triMethylsilyloxy)Methyl)tetrahydro-2H-pyran-2-one iboka rinodzivirira mune organic synthesis.Mapoka ekudzivirira mapoka enguva pfupi anoshanda ayo anoshandiswa kuchengetedza chaiwo reactive nzvimbo pamorekuru panguva yemakemikari reaction.Panyaya ye (3R,4S,5R,6R) -3,4,5-tris(triMethylsilyloxy) -6-((triMethylsilyloxy)Methyl)tetrahydro-2H-pyran-2-one, mapoka e-triMethylsilyloxy anoita sezvikamu zvinodzivirira. .Mukati mekuita, mapoka aya anodzivirira mamwe mapoka anoshanda kubva mukusangana kusingade, zvichibvumira maitiro anodiwa kuti aenderere mberi zvakanaka.Mushure mokunge maitiro apera, mapoka e-triMethylsilyloxy anogona kubviswa nyore nyore, achiratidza mapoka ekutanga anoshanda.Kumwe kushandiswa kwe (3R,4S,5R,6R) -3,4,5-tris(triMethylsilyloxy) -6-((triMethylsilyloxy) Methyl)tetrahydro-2H-pyran-2-imwe iri mukugadzirwa kweorganic compounds.Inogona kushandiswa sechivakwa chekuvaka kuvaka zvivakwa zvakaomarara.Yayo yakasarudzika yemakemikari zvimiro uye reactivity inoita kuti ive chishandiso chakakosha mukuvandudza kwemakemikari matsva.Makemikari anogona kushandisa (3R, 4S, 5R, 6R) -3,4,5-tris(triMethylsilyloxy) -6-((triMethylsilyloxy)Methyl)tetrahydro-2H-pyran-2-imwe kuunza mamwe mapoka anoshanda kana kugadzira chaiwo mamorekuru. scaffolds yekudzidza zviitiko zvebhayoloji zvemakomboni kana kugadzira mishonga mitsva. Pamusoro pazvo, komputa iyi inogona kuwana mashandisirwo mundima yesainzi.Kuvapo kwayo seboka rinoshanda mumorekuru kunogona kupa zvimwe zvinodikanwa kuzvinhu.Semuenzaniso, inogona kuwedzera kunyungudika mune chaiyo zvinonyungudutsa kana kunatsiridza firimu-kugadzira zvinhu, zvichiita kuti ishandiswe mukuputira kana kunamira.(3R,4S,5R,6R) -3,4,5-tris(triMethylsilyloxy) -6-(( triMethylsilyloxy)Methyl)tetrahydro-2H-pyran-2-one ikomboni ine hunyanzvi ine kushandiswa kwakasiyana-siyana muzvikamu zvakasiyana zvesainzi nemaindasitiri.Kugona kwayo kuita seboka rinodzivirira uye kushanda sechivako chekuvaka mumakemikari ekugadzira, pamwe nekugona kwayo kushandiswa musainzi yezvinhu, inoita kuti ive chinhu chakakosha mukugadzirwa kwemamorekuru uye zvinhu.Nekudaro, mashandisirwo ayo chaiwo uye mashandisiro anogona kusiyana, zvichienderana nezvinodiwa uye zvinangwa zveimwe sainzi kana indasitiri purojekiti.