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4-(4-Fluorophenyl)-6-Isopropyl-2-[(N-Methyl-N-Methylsulfonyl)Amino]Pyrimidinyl-5-Yl-Formyl, inozivikanwawo seFIMPA, ikemikari yakagadzirwa nemaitiro akaoma ane simba. zvikumbiro mukutsvagisa mishonga nekuvandudzwa kwezvinodhaka.Inotsanangurwa se pyrimidine derivative neboka reformyl rakabatanidzwa ne5th carbon atomu, uye 4-fluorophenyl neboka reisopropyl rakabatanidzwa kune 4th uye 6th carbon atomu, zvichiteerana.Chimwe chekushanda kwakakosha kweFIMPA chiri mumunda we tsvakurudzo yekenza.Pyrimidine derivatives yakadzidzwa zvakanyanya kune yavo antitumor properties, uye FIMPA inoratidza kugona senge anticancer agent.Zvimiro zvayo zvinoita kuti ive mumiriri anovimbisa kuvharisa ma enzymes akakosha kana ma receptors anobatanidzwa mukukura kwebundu uye kufambira mberi.Vatsvagiri vanogona kushandura chimiro cheFIMPA zvakare kuti chiwedzere simba rayo, kusarudza, uye pharmacokinetic zvimiro zvekuwedzera kurapa kenza.Kupfuurirazve, FIMPA inogona kuita senge scaffold yemamorekuru yekugadzira vamiriri vezvinodhaka vakananga kune zvimwe zvirwere.Chimiro chayo chakasiyana chinobvumira kubatanidzwa kwemapoka akasiyana anoshanda, ayo anogona kuita basa rakakosha mukudyidzana neakananga mamorekuru anotangwa.Izvi zvakasiyana-siyana zvinoita kuti FIMPA ive chishandiso chakakosha mumakemikari emushonga pakugadzira zvinyowani zvekurapa kurwisa zvirwere zvakasiyana-siyana senge neurological kusagadzikana kana zvirwere zvinotapukira.Kuwedzera kune ayo anogona kurapa maapplication, FIMPA inogona kushandiswa mukubatanidza mamwe akaomarara organic komisheni.Mapoka ayo anoshanda anoshanda, akadai seformyl uye sulfonyl mapoka, anogona kushanda senzvimbo dzekuwedzera makemikari ekugadzirisa.Vatsvakurudzi vanogona kushandisa FIMPA sechinhu chekutanga kana kuti pakati pepakati kuti vawane zvigadzirwa zvakasiyana-siyana, izvo zvinogona kuongororwa nokuda kwemabasa avo ehupenyu kana kushandiswa sezvivakwa zvekuvaka kwekugadzirwa kwemamwe mamorekuru akaoma. -2 - [(N-Methyl-N-Methylsulfonyl) Amino]Pyrimidinyl-5-Yl-Formyl (FIMPA) inoratidzira vimbiso inogona kuitika munzvimbo dzakasiyana-siyana dzekutsvakurudza kwemishonga uye kukura kwezvinodhaka.Chimiro chayo chakasiyana uye mapoka anoshanda anoita kuti ive chishandiso chakakosha chekugadzira vatsva vezvinodhaka kana kubatanidza yakaoma organic komisheni.Kuwedzera kuongorora uye optimization yezvivakwa zveFIMPA zvinogona kutungamira mukuwanikwa kweanoveli ekurapa vamiririri uye kubatsira mukufambira mberi mumunda wemakemikari ekurapa.