Makonzo akaiswa muyero mumwechete wemiti yakabva phenolic antioxidant Quercetin (QC) mukusununguka, liposome yakavharidzirwa uye galactosylated liposome yakavharidzirwa mafomu 2 h isati yasvika hepatotoxic dose ye carbontetrachloride (CCl4, 40% v / v mumafuta omuorivhi, 1 ml / kg b .wt).Pakati peaya matatu akasiyana mafomu eQC akaedzwa, chete galactosylated liposomal QC yakapa chengetedzo yakakosha kubva kuCCl4 induced hepatic oxidative kukuvara.Mushure me24 h yejekiseni (SC) masero ehepatic emakonzo akawanikwa achinetseka neCCl4 yakakonzera oxidative kukuvara uye yakatariswa nekuwedzera kwehuwandu hwe conjugated diene muhepatic membrane.Kuwedzera kwakapetwa kaviri mu conjugated diene nekuiswa kweCCl4 kwakaderedzwa kusvika kune yakajairika nhanho negalactosylated liposomal QC pre-kurapa.Carbontetrachloride yakakonzera kukuvara kwe membrane mumasero ehepatic uye yakatongwa neropa serum pathological uye chiropa tishu histopathological kuongorora.Kukuvadzwa kweMembrane nekuiswa kweCCl4 kwakawedzera kuongororwa nekudzikira kwechikamu cheplasma membrane (PM) yakasungwa enzyme Na+/K+ ATPase basa uye yakawedzerwa chete nekutanga kurapwa kwegalactosylated liposomal QC.Carbontetrachloride yakakonzera kuderera kukuru mune enzymatic uye molecular endogenous antioxidant mazinga muhepatic masero.Kuora mwoyo mu antioxidant system mumasero eropa kwakadziviswa zvachose nechiyero chimwe chegalactosylated lipsosomal QC isati yasvika CCl4 kurapwa.Chiropa chinotora QC chakafungidzirwa mushure me2 h yejojo ye flavonoid (8.9 micromol / kg uremu hwemuviri) (yakasununguka kana liposomal mafomu) uye 85% yejojo yeQC yakawanikwa yakawanikwa muchiropa munyaya ye galactosylated liposomal QC.Ipo chete 25% yejojo jekiseni yakaonekwa muchiropa apo imwe yakafanana yakawanda yemahara QC yakaiswa.Carbontetrachloride yakakonzerawo shanduko mu membrane fluidity uye yakaongororwa nekudzikira kwe membrane micro-viscosity.Kusununguka kweQC kusati kwaitwa kwakaguma pasina kudzivirirwa kubva kuCCl4 kunokonzera kuwedzera kwehepatic membrane fluidity, asi galactosylated liposomal QC yakashandisa kudzivirira kwakakosha pakuwedzera.Migumisiro yechidzidzo ichi yakaratidza kuti QC mu galactosylated liposome inogona kushandisa kudzivirirwa kukuru kune CCl4 inokonzerwa nekukuvara kwehepatocellular.
