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(4R-Cis) -1,1-Dimethylethyl-6-[2--[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4--[(phenylamino)carbonyl]-1H-pyrrol -1-yl] ethyl] -2,2-dimethyl-1,3-dioxane-4-acetate isanganiswa ine makemikari akaoma.Kunyange zvazvo ruzivo rwakananga pamusoro pemashandisirwo emukomboni uyu rungave rushoma, tinogona kukurukura mashandisirwo ayo angaita zvichienderana nemaitiro ayo uye maitiro akajairika emakomponi akafanana.Kuvapo kweiyo dioxane moiety muchikamu ichi kunoratidza kuti inogona kunge ine zvinonyungudutsa kana kushandiswa. se solubilizing agent.Dioxane inonyungudutsa yakajairika, kunyanya mu organic chemistry, sezvo iri mvura-inosanganiswa uye ine yakanaka solubility kune dzakasiyana siyana organic mamorekuru.Kuvapo kwe dioxane moiety mukomboni iyi kunoratidza kuti inogona kunge iine zvinhu zvakafanana zvekunyunguduka.Zvakare, zvikamu zvemuumbirwo zvekomboni iyi, zvakaita semapoka efluorophenyl nephenylamino carbonyl, anoratidza zvingangoita biological chiitiko.Fluorine inotsiva mune organic komisheni inogona kuwedzera yavo pharmacokinetic zvimiro, zvichigona kuwedzera potency yavo kana bioavailability.Kuvapo kweboka re phenylamino carbonyl rinogona kuratidza kukwanisa kwekubatana nezvinangwa zvehupenyu, zvichida kutungamirira kumigumisiro yekurapa.Kubva pane izvi zvekugadzirisa maitiro, zvinogoneka kuti chikamu ichi chinogona kuva nekushandiswa mumakemikari emishonga kana kugadzirwa kwezvinodhaka.Inogona kuongororwa semusanganiswa unotungamira wekugadzirwa kwemishonga mitsva yakanangana nezvirwere.Zvisinei, zvakakosha kuti ticherechedze kuti zvimwe zvidzidzo zvinodiwa kuti zvionekwe zvazvinoita zvemishonga, kusanganisira kushanda kwayo, magadzirirwo echiito, uye zvingangoitika.Pamusoro pemakemikari emishonga, iyi nitronyl kana pyrrole moiety yemukomboni inogona kupa pfungwa yekushandisa mune zvesainzi. kana sechikamu mumakemikari synthesis.Nitronyl uye pyrrole zvinobuda zvakaongororwa kuti zvigone kushandiswa se organic conductor, catalysts, kana zvivharo zvekuvaka kune zvimwe zvakaoma zvimiro.Zvisinei, zvikumbiro izvi zvaizoda kuwedzera kuferefetwa uye optimization of synthesis nzira.Pakazere, komisheni (4R-Cis) -1,1-Dimethylethyl-6-[2--[2- (4-fluorophenyl) -5-(1-) methylethyl) -3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]ethyl]-2,2-dimethyl-1,3-dioxane-4-acetate inoratidza mikana yekushandiswa mumakemikari emishonga, zvinhu sainzi, kana makemikari synthesis.Nekudaro, zvakakosha kuita tsvakiridzo yakawandisa kuti iongorore zvimiro zvayo, kugadzira nzira dzakakodzera dzekubatanidza, uye kuona mashandisiro ayo chaiwo mumunda wega wega.