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5-(Bromomethyl) -4- (4-fluorophenyl) -6-isopropyl-2--[methyl(methylsulfonyl) amino]pyrimidine ikemikari inobatanidza inowana kushandiswa mukutsvakurudza kwakasiyana-siyana, mishonga, uye kushandiswa kwemabhizimisi.Mushonga uyu unozivikanwa nekusiyana-siyana uye kugona kwaunobata pakugadzira mamorekuru nemishonga nekuda kwechimiro chayo uye mapoka anoshanda. zvinodhaka.Kuvapo kweatomu yebromine, atomu yefluorine, boka reisopropyl, uye pyrimidine mhete yechimiro inoita kuti ive chivakwa chinoyevedza chekugadzira mamorekuru ane anodiwa.Makemikari uye vatsvakurudzi vemishonga vanogona kushandura uye kushanda kwekomisheni iyi kuti izivise maitiro chaiwo kana maitiro ekugadzirisa anobatsira kune zvakanangwa zvinodhaka zvinodhaka kana kusimbiswa kwe pharmacokinetic properties.Uyezve, kuvapo kwemapoka emethyl uye methylsulfonyl mukomboni inoita kuti zvive zvakakosha mukugadzirwa kwehupenyu.Boka remethylsulfonyl rinogona kuita maitiro akasiyana-siyana, senge nucleophilic displacement, elimination, kana oxidation, zvichibvumira kuunzwa kwemapoka anoshanda akasiyana mune inotangwa molecule.Izvi zvakasiyana-siyana zvinoita kuti zvive zvakakosha pakugadzira makomisheni akaomarara munzvimbo yerabhoritari. Pamusoro pazvo, chimiro chekomboni inoita kuti igone kubatsira muzvidzidzo zvetsvakiridzo.Iyo atomu yefluorine uye zvimwe zvinotsiva zvinogona kubatsira kune chaiyo yekomboni yemuviri kana kemikari zvimiro, zvichiita kuti zvive zvakanaka kuferefeta zvimwe zviitiko kana sechinhu chinongedzo chekuenzanisa zvidzidzo.Vatsvakurudzi vanowanzoshandisa mishonga yakadaro kuti vanzwisise kupindirana kwehupenyu, kudzidza maitiro kinetics, kugadzira nzira itsva dzekugadzira, kana kuwedzera kushanda kwemaitiro emabhizimisi aripo. 4-fluorophenyl) -6-isopropyl-2--[methyl(methylsulfonyl) amino]pyrimidine inogona kusiyana zvichienderana nenzvimbo chaiyo yekutsvakurudza kana indasitiri.Zvishandiso zvekomboni iyi zvinodarika izvo zvambotaurwa, uye kubatsira kwaro kunogona kuongororwa nevemakemikari, pharmacologists, biochemists, uye mamwe masayendisiti ane chekuita nekuwanikwa kwezvinodhaka, sainzi yezvinhu, kana tsvakurudzo yemamolecular.Muchidimbu, 5-(Bromomethyl) -4 -(4-fluorophenyl) -6-isopropyl-2--[methyl(methylsulfonyl)amino]pyrimidine isanganiswa yakasiyana-siyana inobata chivimbiso mumishonga, kemikari, uye tsvakurudzo yeindasitiri.Mamiriro ayo chaiwo uye mapoka anochinja anoita kuti ive chivakwa chinoyevedza chekugadzira mamorekuru emishonga uye kuongorora maitiro akasiyana emakemikari.Zvishandiso zvekomboni iyi zvakapamhama, uye kumwezve kuongororwa kwezvivakwa zvayo kunogona kugadzira nzira yekufambira mberi mundima dzakati wandei dzesainzi.