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5,6-Dihydro-3- (4-morpholinyl) -1-[4- (2-oxo-1-piperidinyl) phenyl] -2 (1H) -pyridinone, inozivikanwawo seDMPHP, inhengo yeheterocyclic ine maitiro akasiyana-siyana. mumakemikari emishonga uye kuwanikwa kwezvinodhaka.Heino tsananguro yekushandiswa kwayo mumashoko anenge 300. DMPHP inozivikanwa nokuda kwekugona kwayo seine simba uye inosarudza inhibitor yemamwe enzymes uye zvinogamuchirwa mumuviri womunhu.Imwe yemashandisirwo ayo ekutanga ari mumunda we kinase inhibition.Kinase ma enzymes anoita basa rakakosha mumaseru ekusaina nzira uye anowanzo kubatanidzwa muzvirwere zvakasiyana siyana, kusanganisira cancer.DMPHP yakawanikwa ichidzivirira zvakananga kinases, nekudaro ichikanganisa kusaina kusaina macascades anobatsira mukufambira mberi kwechirwere.Izvi zvinoita kuti ive mumiriri anovimbisa wekuvandudzwa kwemishonga inotarirwa yezvirwere zvakasiyana-siyana, kusanganisira kenza, kuzvimba, uye zvirwere zvetsinga.Uyezve, DMPHP yakaratidza kukwanisa munharaunda ye-anti-inflammatory and immunomodulatory activity.Kuzvimba kupindurwa kwechisikigo kwemuviri kune kutapukirwa kana kukuvara asi kunogona kuve kusingagumi uye kutungamirira kuzvirwere zvakasiyana.DMPHP yakaratidza kugona kuvharidzira dzimwe nzira dzepro-inflammatory, kuderedza kugadzirwa kwevayananisi vanopisa.Iyi pfuma inoita kuti ive chinhu chakakosha mukugadzirwa kwemishonga inorwisa-kupisa, inobatsira mukurapa kwemamiriro ezvinhu akadai se rheumatoid arthritis, inflammatory bowel disease, uye asthma.DMPHP yakaongororwawo kuti inokwanisa sei seanorapisa kana marwadzo-relieving agent. .Kurwara kusingagumi inyaya yehutano yakakosha, uye sarudzo dzemazuva ano dzekurapa dzinowanzove nemiganhu kana zvisingadiwi mhedzisiro.DMPHP yakaratidza mhedzisiro yeanalgesic muzvidzidzo zvepreclinical, ichiratidza kugona kwayo senge riini rekurapa rekugadzirisa marwadzo.Nokugadzirisa zvakagadziriswa zvinogamuchirwa uye neurotransmitters zvinobatanidzwa mukunzwa marwadzo, DMPHP inogona kupa imwe nzira yekugadzirisa marwadzo ine zvingangoita zvishoma.Neurological mamiriro akadai sechirwere cheAlzheimer uye chirwere cheParkinson anosanganisira maitiro akaomarara uye dysregulation yeakasiyana receptors uye ma enzymes muuropi.DMPHP yakadzidzwa nezve kugona kwayo seyeuroprotective agent uye nekugona kwayo kuwedzera kugona kwekuziva.Nekunongedza mareceptor chaiwo uye nzira dzinobatanidzwa mune neurodegenerative kusagadzikana, DMPHP inobata chivimbiso sekupindira kwekurapa kweaya mamiriro akaoma. 1-piperidinyl) phenyl] -2 (1H) -pyridinone (DMPHP) isanganiswa yakasiyana-siyana inogona kushandiswa mu kinase inhibition, anti-inflammatory activity, analgesia, uye neuroprotection.Kugona kwayo kusarudza kusarudzika ma enzymes uye mareceptor anobatanidzwa munzira dzechirwere anoita kuti ive mumiriri anokwezva wekutsvaga zvinodhaka uye kupindira kwekurapa.Kumwe kutsvagisa nekusimudzira kunogona kuburitsa mamwe mashandisirwo uye kukwidziridza zvivakwa zvayo kune chaiwo zviratidzo.