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6-Acetyl-8-cyclopentyl-5-methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]pyrido[2,3-d]pyrimidin-7(8H)-imwe hydrochloride isanganiswa. nezvinogona kushandiswa mukutsvaga kwemishonga uye kugadzirwa kwezvinodhaka.Chimiro chayo chakasiyana chemolecular chinopa mikana yekuongorora mashandisirwo ayo ekurapa.Komboni iyi ndeyemhuri yepyrido[2,3-d]pyrimidinone, iyo yakadzidzwa zvakanyanya nekuda kwemabasa ayo emishonga.Kuvapo kweboka reacetyl rinoratidza kushamwaridzana kunogona kuitika nema enzymes anobatanidzwa mumaserura maitiro.Inogona kunge ine inhibitory effects pama enzymes akaita sekinases kana maproteases, zvichiita kuti ive mumiriri anovimbisa wekugadzirwa kwe enzyme-specific inhibitors.Mapoka e-cyclopentyl uye methyl muhutano anobatsira kune chimiro che lipophilic.Ichi chivakwa chinochibvumira kuyambuka zviri nyore zvipingamupinyi zvebiological, ichiwedzera kugona kwayo semumiriri wezvinodhaka.Inogona kunge yakagadziridza kupera uye bioavailability, zvichiita kuti ive yakakodzera kushandiswa kwemuromo uye kugoverwa kwehurongwa.Mapoka e1-piperazinyl uye 2-pyridinyl aripo mumushonga anopa maitiro akasiyana-siyana ekushandisa kwayo mukugadzirwa kwezvinodhaka.Piperazine derivatives inozivikanwa zvakanyanya mumakemikari ekurapa nekuda kwekuita kwavo kwehupenyu.Boka repiperazine rinogona kubatsira kune receptor kusunga uye modulate pharmacokinetic zvinhu.Uyezve, boka re pyridine rinowanzobatanidzwa mukubatana kwe-ligand-receptor, sezvo pyridine ring systems inogona kuumba hydrogen bonds nedzimwe nzvimbo dzekugamuchira.Zvinhu izvi zvinoita kuti chikwata ichi ive ligand yezvipo zvakasiyana-siyana, kusanganisira G protein-coupled receptors. Tichifunga nezve pyrido [2,3-d] pyrimidinone scaffold uye kuvapo kweboka repiperazine, chikwata chinogona kuongororwa seanorwisa kenza. .Inogona kuratidza cytotoxic mhedzisiro inopesana nekenza maseru kuburikidza nekudzivirirwa kweiyo nzira yekusaina yakabatana nekuwanda kwesero.Zvimwe zvidzidzo zvinosanganisira in vitro uye mu vivo mienzaniso inogona kuongorora kukwanisa kwayo se anti-tumor agent.Uyezve, iyo compound's pyrido [2,3-d] pyrimidinone core inogona kuchinjwa kuti iite zvakananga zvirwere kana mamiriro.Nekuunza mapoka akakodzera anoshanda kana zvinotsiva, kusarudzwa kwaro uye simba rinogona kukwidziridzwa, zvichibvumira kugadzirwa kweakanyanya kurapa maitiro.Muchidimbu, 6-Acetyl-8-cyclopentyl-5-methyl-2-[[5-(1--) piperazinyl) -2-pyridinyl]amino]pyrido[2,3-d]pyrimidin-7(8H) -one hydrochloride inobata zvingave munzvimbo dzakawanda dzekutsvakurudza kwemishonga.Zvimiro zvaro zvinobvumira kuferefetwa mune enzyme inhibition, receptor kusunga, uye anti-gomarara chiitiko.Kumwe kuongorora nekugadzirisa kwechimiro chayo chepakati kunogona kupa vanyoreri vezvinodhaka vane hunyanzvi hwekuita uye humbowo hwezvinangwa zvakasiyana-siyana zvekurapa.