Albendazole Cas: 54965-21-8
| Catalog Number | XD91873 |
| Product Name | Albendazole |
| CAS | 54965-21-8 |
| Molecular Formula | C12H15N3O2S |
| Molecular Weight | 265.33 |
| Storage Details | 2-8°C |
| Harmonised Tariff Code | 29332990 |
Chigadzirwa Specification
| Chitarisiko | White crystalline powder |
| Assay | 99% min |
| Melting point | 208-210 °C |
| density | 1.2561 (yakaomarara fungidziro) |
| refractive index | 1.6740 (kufungidzira) |
| solubility | Inenge isinganyungudike mumvura, inonyungudika zvakasununguka muanhydrous formic acid, yakanyanya kunyungudika zvishoma mumethylene chloride, isinganyungudika mu ethanol (96 muzana). |
| pka | 10.72±0.10(Zvakafanotaurwa) |
| Mvura Solubility | 0.75mg/L(209 ºC) |
Albendazole mushonga unoshandiswa kurapa zvirwere zvinokonzerwa nemaparasite.Inogona kupihwa kurapa isingawanzo hutachiona hwehuropi (neurocysticercosis) kana inogona kupihwa kurapa hutachiona hunokonzera manyoka akakosha (microsporidiosis).
Kubva kubenzimidazole, albendazole mushonga une antihelmintic spectrum yakakura.Inoratidzira antihelmintic effect inopesana necestodes yakaoma uye nematodes nekuvhara nzira yeglucose kutorwa nemaparasite, iyo inoratidzwa mukuderera kweglycogen reserves uye kunotevera kuderedzwa kwezinga readenosintriphophate.Somugumisiro, utachiona hunomira kufamba uye hunofa.Inoshandiswa pahutachiona hweAcaris lumbricoides, Ancylostoma duodenale, Necator americanus, Enterobius vermicularis, uye Trichuris trichiura.Mazwi akafanana emushonga uyu SKF 62979 nemamwe.
Methyl 5-(propylthio)-2-benzimidazolecarbamate (Eskazole,Zentel) ndeye wide-spectrum anthelmintic iyo isiri kutengeswa kuNorth America parizvino.Inowanikwa kubva kumugadziri pane ane tsitsi kushandisa hwaro.Albendazole inoshandiswa zvakanyanya pasi rose pakurapa intestinalnematode infection.Inoshanda semushonga mumwe chete wekurapa ascariasis, New and Old World hookworm zvirwere, uye trichuriasis.Multiple-dose therapy nealbendazole caneradicate pinworm, threadworm, capillariasis, clonorchiasis, uye hydatid chirwere.Kushanda kwealbendazole kurwisa tapeworms (cestodes) kunowanzo chinja uye kusinganakidze.
Albendazole inoitika sehupfu hwekristaro chena isinganyungudika mumvura.Kutorwa kwemuromo kwealbendazoleis kunowedzerwa nekudya kwemafuta.Mushonga unopinda nekukurumidza uye yakakura yekutanga-pass metabolism kune sulfoxide, inova iyo inoshanda fomu muplasma.Kubviswa kwehafu yehupenyu hwe sulfoxide kubva ku10 kusvika ku15 maawa.Kunyanya biliaryexcretion uye enterohepatic recycling yealbendazolesulfoxide inoitika.Albendazole kazhinji inoshivirira mune imwechete-dose therapy ye intestinal nematodes.The highdose, kurapa kwenguva refu kunodiwa clonorchiasis orechinococcal chirwere kurapa kunogona kuguma nemigumisiro yakaipa yakadai sekuora mwoyo kwemwongo, kukwidziridzwa kwema enzymes echiropa, uye alopecia.
Albendazole ine huwandu hwakawanda hwekuita kurwisa intestinal nematodes uye cestodes, pamwe nezviropa zvechiropa Opisthorchis sinensis, Opisthorchis viverrini, uye Clonorchis sinensis.Iyo zvakare yakashandiswa zvinobudirira kurwisa Giardia lamblia.Albendazole mushonga unoshanda we hydatid cyst disease (echinococcosis), kunyanya kana ichiperekedzwa nepraziquantel.Inoshandawo mukurapa cerebral uye spinal neurocysticercosis, kunyanya kana ikapiwa nedexamethasone.Albendazole inokurudzirwa kurapwa kwegnathostomiasis.
