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Imwe nzira yakakosha yekurapa yemhando ye2 chirwere cheshuga mellitus ndeye kushandiswa kwevamiririri vanogona kuderedza postprandial hyperglycaemia nekudzivisa ma carbohydrate digesting enzymes.Chidzidzo chezvino chakaongorora mhedzisiro yebioassay-inotungamirwa yakatorwa uye zvidimbu zvemichero yakaomeswa pericarp yePhaleria macrocarpa, yechinyakare anti-diabetic chirimwa, pane α-glucosidase uye α-amylase, mukuda kunzwisisa kwavo anti-diabetic maitiro, se. pamwe chete nekugona kwavo kuvharidzira chiito pa postprandial glucose kuwedzera.Methanol extract (ME), yakawanikwa nekutevedzana kwekunyungudutsa, iyo inonyanya kushanda mvura-mvura n-butanol chikamu (NBF) uye flash column chromatographic sub-fraction (SFI), yakaongororwa. nokuti in vitro α-glucosidase (mbiriso) uye α-amylase (porcine) basa inhibition.Uyezve, kuvimbiswa mu vivo bvunzo kwakaitwa mu streptozotocin-induced diabetic rats (SDRs) vachishandisa oral glucose, sucrose uye starch kushivirira bvunzo.Pamusoro wepamusoro wakashandiswa (1 00 μg / ml), NBF yakaratidza yakanyanya inhibition kurwisa α-glucosidase. 75%) uye α-amylase (87%) in vitro (IC50 = 2.40 ± 0.23 μg/ml uye 58.50 ± 0.13 μg/ml, zvichiteerana) mune imwe nzira-inotenderera;mhedzisiro inowanikwa inenge 20% yakakwirira kupfuura acarbose (55%), chiyero α-glucosidase inhibitor (IC50 = 3.45 ± 0.19 μg/ml).Iyo ME neSFI yaidzivirirawo α-glucosidase (IC50 = 7.50 ± 0.15 μg/ml uye 11.45 ± 0.28 μg/ml) uye α-amylase (IC50 = 43.90 ± 0.19 μg/ml ± 0.80ml uye 60 μg/ml) zvishoma.Muin vivo zvidzidzo nemakonzo ane chirwere cheshuga, NBF neSFI zvakanyatso dzikisa peak yeropa glucose (PBG) ne15.08% uye 6.46%, uye nzvimbo iri pasi pekushivirira curve (AUC) ne14.23% uye 12.46%, zvichiteerana, mushure mekunetsa kwemuromo sucrose. (P <0.05);nokudaro kusimbisa iyo yakaonekwa in vitro chiito.Izvi zvinoderedza mhedzisiro paPBG neAUC zvakaratidzwawo mukuyedzwa kweglucose uye starch, asi kusvika padanho diki.Izvi zvakawanikwa zvinoratidza kuti P. macrocarpa inogona kuderedza hyperglycaemia mune zvese in vitro uye in vivo mamiriro nekudzivisa zvine simba ma carbohydrate hydrolysing enzymes, zvichiita kuti ive. chirimwa chinoshanda chekutsvaga masikirwo emakomisheni ekutarisira mhando 2 chirwere cheshuga mellitus.