BCIP-Toluidine)5-Bromo-4-chloro-3-indolylphosphate-p-toluidine munyu Cas:6578-06-9 99% Ichena kusvika kuhupfu hwakatsvuka
| Catalog Number | XD90137 |
| Product Name | BCIP-Toluidine)5-Bromo-4-chloro-3-indolylphosphate-p-toluidine munyu |
| CAS | 6578-06-9 |
| Molecular Formula | C8H5BrClNO4P·C7H10N |
| Molecular Weight | 433.62 |
| Storage Details | -15 kusvika -20 °C |
| Harmonised Tariff Code | 29339980 |
Chigadzirwa Specification
| Chitarisiko | Hupfu huchena/hutsvuku |
| Assay | ≥ 99% |
| Melting point | 194-195 ºC |
| Boiling point | 580.2°C pa760 mmHg |
| Flash point | 304.7°C |
| Solubility | DMF: 20 mg/mL |
| Solubility | soluble mu dimethylformamide, isinganyungudika mumvura. |
| Sensitivity | Inonzwa kuchiedza, inonzwa kumhepo, uye inonzwa nekupisa |
Biological chiitiko: BCIP (BCIP p-toluidine munyu; X-phosphate p-toluidine munyu) is chromogenic substrate ye colorimetric yekuona alkaline phosphatase chiitiko.
Shiga toxins (Stxs) inogadzirwa ne enterohemorrhagic Escherichia coli (EHEC), iyo inokonzera kutapukirwa kwevanhu nemhedzisiro inowanzouraya.Vero cell mitsara, inotorwa kubva kuAfrica yegirini tsoko itsvo, inomiririra mwero wegoridhe wekuona cytotoxic mhedzisiro yeStxs.Pasinei nekushandiswa kwavo pasi rose, ruzivo pamusoro pezvimiro zveStx receptor glycosphingolipids (GSLs) uye kuungana kwavo mu lipid rafts kwakashata.Pano tinopa kuongororwa kwakazara kwemaitiro eStx receptor GSLs uye kugovera kwavo kune detergent-resistant membranes (DRMs), iyo yakagadzirwa kubva kuVero-B4 masero uye yakashandiswa se lipid raft yakaenzana.Takaona globotriaosylceramide (Gb3Cer) uye globotetraosylceramide (Gb4Cer) seGSL receptors yeStx1a, Stx2a, uye Stx2e subtypes tichishandisa TLC overlay kuonekwa yakasanganiswa neMS.Izvo zvisingawanzoitiki Stx receptor, globopentaosylceramide (Gb5Cer, Galβ3GalNAcβ3Galα4Galβ4Glcβ1Cer), iyo yakanyatsozivikanwa (pamwe neGb3Cer uye Gb4Cer) neStx2e, yakanyatsogadziriswa.Lipoforms yeStx receptor GSLs yakawanikwa ichinyanya kuchengetedza ceramide moieties inoumbwa ne sphingosine (d18: 1) uye C24: 0 / C24: 1 kana C16: 0 fatty acid.Uyezve, kuitika pamwe chete nelipid raft mamaki, SM uye cholesterol, muma DRMs akakurudzira GSL kushamwaridzana ne membrane microdomains.Ichi chidzidzo chinopa hwaro hwekuwedzera kuongorora kushanda kweiyo lipid raft-yakabatana Stx receptors yehupfu-mediated kukuvara kweVero-B4 masero.
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