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Kukanganisa kwakashata kwakakosha pakupa kusadzivirirwa kune opiate kupindwa muropa sezvinoratidzwa nepamusoro comorbidity yekushungurudzwa kweopiate nekunyanya kuora mwoyo kusagadzikana (MDD).Rodent modhi dzinobatanidza amygdala prodynorphin (Pdyn) semurevereri wezvakaipa zvinokanganisa;zvisinei, uchapupu hwekubatanidzwa kwePDYN mukukanganisa kwevanhu kune zvishoma.Pano, takawana yakaderedzwa PDYN mRNA kutaura mu postmortem yemunhu amygdala nucleus ye periamygdaloid cortex (PAC) mune vese vanoshungurudza heroin uye MDD zvidzidzo.Zvakafanana nevanhu, makonzo ayo anogara achizvibata heroin akange aderedza Pdyn mRNA kutaura muPAC pane imwe nguva yakabatana neiyo yakaipa affective state.Tichishandisa iyo in vivo inoshanda yekufungidzira tekinoroji DREAMM (DREADD-yakabatsira metabolic mepu, apo DREADD inoratidza magadzirirwo anogamuchirwa anongoitwa neanogadzira mishonga), takaona kuti kusarudzwa kuvharirwa kwePdyn-inoratidza neurons mugonzo PAC yakawedzera chiitiko chemetabolism mune yakawedzera amygdala, iyo ndiyo yakakosha substrate yeiyo extrahypothalamic brain stress system.Mukufanana, PAC-chaiyo Pdyn inhibition yakatsamwisa yakaipa kukanganisa-inoenderana nekuchinja kwemuviri uye maitiro.Pamwe chete, chidzidzo chedu chekushandura chinotsigira basa rekusagadzikana kwePdyn muPAC mukushungurudzwa kweopiate kuburikidza nekugadzirisa kushushikana uye kusakanganisa kunokanganisa neurocircuitry inosanganisirwa mukupindwa muropa nenjodzi.