Diethylene triamine pentaacetic acid Cas: 67-43-6 99% White crystalline poda
| Catalog Number | XD90220 |
| Product Name | Diethylene triamine pentaacetic acid |
| CAS | 67-43-6 |
| Molecular Formula | C14H23N3O10 |
| Molecular Weight | 393.3465 |
| Storage Details | Ambient |
| Harmonised Tariff Code | 29224985 |
Chigadzirwa Specification
| Heavy metals | 0.001% max |
| pH | 2 - 3 |
| Fe | 0.001% max |
| Solubility | Inonyungudika zvishoma mumvura, 15% mhinduro inonyungudika mumvura inopisa.Soluble muAlkali yose |
| Assay | 99% min |
| Sulfated ash | 0.1% max |
| Cl | 0.1% max |
| Chitarisiko | White crystalline powder |
Kuwedzera oxidative kusagadzikana pasi pe hyperglycemic mamiriro, kuburikidza nekubatana kweAGEs ne RAGE receptors uye kuburikidza ne activation ye interleukin mediated transcription signing, yakataurwa mukenza.Kugadziridzwa kweprotein kuri kuongororwa nezvemabasa avo mukuvandudza uye kufambira mberi kwegomarara uye mhinduro yeautoantibody pavari iri kuwana kufarira semuongorori wekukurumidza kuonekwa kwechirwere.Ichi chidzidzo chakaongorora shanduko muhistone H1 pakugadziriswa nemethylglyoxal (MG) uye zvazvinoreva mu auto-immunopathogenesis yegomarara.Modified histone yakaratidza kugadziridzwa mune zvinonhuhwirira zvakasara, zvakachinja tyrosine microenvironment, intermolecular cross linking uye chizvarwa cheAGEs.Yakaratidza masking ye hydrophobic patches uye hypsochromic shanduko muANS chaiyo fluorescence.MG zvine hukasha oxidized histone H1 inotungamira mukuunganidzwa kweanoshanda carbonyls.Kure UV CD zviyero zvakaratidza di-carbonyl induced kukwidziridzwa kweiyo alpha chimiro uye th e induction ye beta sheet conformation;uye thermal denaturation (Tm) zvidzidzo zvakasimbisa kugadzikana kwekupisa kweiyo yakagadziridzwa histone.FTIR ongororo yakaratidza amide I band shift, chizvarwa cheboka recarboxyethyl uye N-Cα kudengenyeka mune yakagadziridzwa histone.Ongororo yeLCMS yakasimbisa kuumbwa kweNε-(carboxyethyl) lysine uye elektroni microscopic zvidzidzo zvakaratidza kuumbwa kweamorphous aggregate.Iyo yakagadziridzwa histone yakaratidza yakashandurwa cooperative kusunga neDNA.Yakagadziridzwa H1 yakakonzera masoja ekudzivirira chirwere akakwira mutsuro uye IgG yakasarudzika fomu sera yetsuro dzakabaiwa neH1 yakagadziridzwa yairatidza kusungirirwa kwayo neimmunegen yayo mukuongorora kweWestern Blot.IgG yakaparadzaniswa nesera yevarwere vane kenza yemapapu, kenza yeprostate, gomarara rezamu uye kenza yemusoro nemutsipa dunhu yakaratidza kucherechedzwa kuri nani kweneo-epitopes pane yakagadziridzwa histone, ichiratidza kuvapo kwekutenderera autoantibodies mugomarara.Sezvo mishumo ichikurudzira kubatana pakati peAGE-RAGE axis uye carcinogenesis, glycoxidation yehistone H1 uye immunogenicity yayo inovhura nzira dzekunzwisisa basa re glycoxidatively yakakuvadzwa mapuroteni enyukireya mugomarara.
