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Flucytosine, inozivikanwawo se 5-fluorocytosine kana 5-FC, mushonga wekugadzira antifungal unonyanya kushandiswa kurapa hosha dzefungal.Inorondedzerwa se antimetabolite, zvinoreva kuti inokanganisa maitiro emagetsi emasero efungal, zvichiita kuti avhare kana kufa.Flucytosine inowanzoitwa pamwe chete nemamwe maantifungal agents kuti aite zvakanaka.Imwe yekushandiswa kwakakosha kweflucytosine iri mukurapa kwezvirwere zvefungal, kunyanya izvo zvinokonzerwa nemarudzi Candida uye Cryptococcus.Inowanzoshandiswa pamwe chete neimwe antifungal agent, yakadai seamphotericin B kana fluconazole, kuwedzera basa rayo rekudzivirira.Flucytosine inoshanda nekupinda fungal maseru uye kutendeuka kuita 5-fluorouracil, cytotoxic antimetabolite.5-fluorouracil inobva yakanganisa kuumbwa kwefungal RNA neDNA, nokudaro ichidzivisa fungal kukura uye kudzokorora.Iyi synergistic nzira inobatsira kurwisa huwandu hwakawanda hwehutachiona hwefungal uye kuwedzera kushanda kwekurapa.Kumwe kushandiswa kwakakosha kweflucytosine kuri mukurapa kweCryptococcus neoformans meningitis, hutachiona hunogona kutyisa hupenyu hunokanganisa membrane dzakatenderedza uropi uye musana.Flucytosine inoonekwa seimwe yenzira dzekutanga dzekurapa pamwe neamphotericin B pakurapwa kwechirwere ichi.Iko kusanganisa kurapa kunobatsira kukunda zvipimo zvemushonga wega wega uye kuwana yakakwirira yekurapa mitengo.Flucytosine inosvika mazinga akakwana mu cerebrospinal fluid, ichibvumira kuti ibudirire kutarisana nehutachiona hwehutachiwana mukati mehutano hwehutano.Zvisinei, kushandiswa kwayo kunogona kuderedzwa nekuda kwengozi yekuvandudza kushorwa, sezvo fungus inogona kuwana kuchinja kunoita kuti isanyanya kubatwa nemishonga.Kunyatsocherechedza uye kuongorora nguva nenguva kwemhinduro yekurapa kunokosha pakushandisa flucytosine kuti uone migumisiro yekurapa yakakodzera.Kunyange zvazvo flucytosine inowanzobvumirwa zvakanaka, inogona kuva nemigumisiro yakaipa.Zvinowanzoitika zvinosanganisira kuvhiringidzika kwegastrointestinal, zvakadai sekusvotwa, kurutsa, uye manyoka.Inogonawo kukonzera kudzvinyirirwa kwemwongo, izvo zvinogona kukonzera kuderera kwekugadzirwa kwemasero eropa.Nguva dzose kuongororwa kweropa kunowanzoitwa kutarisa kuverenga kwemasero eropa panguva yekurapa.Muchidimbu, flucytosine mushonga unorwisa fungal unoshandiswa mukubatanidza kurapa kwezvirwere zvefungal, kunyanya izvo zvinokonzerwa neCandida uye Cryptococcus marudzi.Inoshanda nekukanganisa fungal nucleic acid synthesis, ichitadzisa kukura kwavo uye kudzokorora.Flucytosine inowanzoshandiswa pamwe chete nemamwe maantifungal agents uye inonyanya kukosha mukurapa Cryptococcus neoformans meningitis.Zvisinei, kushandiswa kwayo kunoda kunyatsotariswa nekuda kwengozi yekupikisa uye zvinogona kuipa.