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Islet amyloid polypeptide (IAPP; inozivikanwawo seamylin) inokonzera kuumbwa kweislet amyloid mumhando yechipiri yechirwere cheshuga, uye IAPP-induced toxicity inofungidzirwa kuti inobatsira mukurasikirwa kwe-β-cell mass inobatanidza nezvikamu zvekupedzisira zvechirwere cheshuga chechipiri.Islet amyloid formation inogonawo kuita basa mukutadza kwegraft mushure mekusimwa.IAPP inogadzirwa seprohormone, pro-islet amyloid polypeptide (proIAPP), uye inogadziriswa mune zvakavanzika granules epancreatic β-cell.Zvikamu zvakagadziridzwa mafomu eproIAPP anowanikwa mune amyloid deposits;chinonyanya kukosha ndeye 48-yakasara yepakati, proIAPP (1-48), iyo inosanganisira N-terminal pro-extension, asi iyo yakanyatsogadziriswa paC-terminus.Kugadziriswa kusina kukwana kunogona kuita basa mukugadzirwa kweislet amyloid nekusimudzira kushamwaridzana ne sulfated proteoglycans ye extracellular matrix, iyo, iyo, inokurudzira kuumbwa kweamyloid.Isu tinoratidza kuti acid fuchsin (3-(1-(4-amino-3-methyl-5-sulphonatophenyl)-1-(4-amino-3-sulphonatophenyl)methylene)cyclohexa-1,4-dienesulphonic acid), iri nyore. sulfonated triphenyl methyl derivative, inhibitor ine simba yekuumbwa kwemamyloid neproIAPP (1-48) yepakati.Iyo yakanyanya kuomesesa triphenyl methane inotorwa inokurumidza girini FCF {ethyl-[4-[[4--[ethyl-[(3-sulfophenyl)methyl]amino]phenyl]-(4-hydroxy-2-sulfophenyl)methylidene]-1-cyclohexa -2,5-dienylidene]-[(3-sulfophenyl) methyl]azanium} inodzivisawo kuumbwa kwemamyloid neIAPP uye proIAPP yekugadzirisa pakati.Ose makomponi anotadzisa kuumbwa kweamyloid nemisanganiswa yeproIAPP yepakati uye modhi glycosaminoglycan heparan sulfate.Acid fuchsin zvakare inhibisa glycosaminoglycan-mediated amyloid kuumbwa neIAPP yakakura.Kukwanisa kuvharidzira kuumbwa kwemaamyloid hakusi kungokonzerwa nemakemikari ari sulfonated, sezvo sulfonated inhibitor yeamyloid-β, tramiprosate, haisi inhibitor yeamyloid formation ne proIAPP (1-48).