Furazolidone Cas: 67-45-8
| Catalog Number | XD91885 |
| Product Name | Furazolidone |
| CAS | 67-45-8 |
| Molecular Formula | C8H7N3O5 |
| Molecular Weight | 225.16 |
| Storage Details | Ambient |
| Harmonised Tariff Code | 29349990 |
Chigadzirwa Specification
| Chitarisiko | Yellow powder |
| Assay | 99% min |
| Melting point | 254-256°C (Zvita.) |
| Boiling point | 366.66°C (yakaomarara fungidziro) |
| density | 1.5406 (yakaomarara fungidziro) |
| refractive index | 1.7180 (kufungidzira) |
| Fp | 2 °C |
| solubility | formic asidhi: soluble50mg/mL |
| pka | -1.98±0.20(Zvakafanotaurwa) |
| Sensitive | Chiedza Sensitive |
| λmax | 365nm(DMSO)(lit.) |
| Kugadzikana | Yakagadzikana.Inopisa.Hazvienderani neakasimba oxidizing agents. |
Iyo antibacterial spectrum yefurazolidone yakafanana neyefurazolidone.Semushonga unorwisa utachiona, unoshanda mukurapa Salmonella, Shigella, Escherichia coli, Proteus, Streptococcus, uye Staphylococcus aureus.Utachiona hausi nyore kugadzira kusanzwa nemishonga mushonga uyu.Iyo zvakare haina kuchinjika-kupikisa nemishonga inorwisa mabhakitiriya emhando yesulfa.Inonyanya kushandiswa kuchipatara kurapwa kwemanyoka, enteritis, typhoid, paratyphoid uye topical kurapwa kwevaginal trichomoniasis.
2. Chigadzirwa chacho chinonzi fungicide ine yakakura antibacterial spectrum.Semushonga unorwisa utachiona, unoshanda pakurapa akasiyana mabhakitiriya eGram-positive uye akaipa anosanganisira Escherichia coli, Bacillus anthracis, uye Paratyphoid bacilli.Haisi kungoshanda chete mukurapa kwemanyoka, enteritis, asiwo kushandiswa pakurapa zvirwere zvemukadzi.Mumakore achangopfuura, ine simba rakanaka rekurapa typhoid fever.Sekuwedzera kwemishonga yemhuka uye zvinwiwa, ine yakasarudzika antibacterial mhedzisiro paSalmonella, Escherichia coli uye Salmonella pullorum uye zvakare ine imwe inhibitory mhedzisiro paprotozoa (coccidia bacteria, nezvimwewo) uye ita kuti isanyanya kushanduka kurwisa zvinodhaka.Idiki shoma yefurazolidone yakashandiswa kune mamwe maapplication (akadai sependi inonyungudika nemvura uye mapepa emapepa) sefungicides.
3. Mushonga unorwisa utachiona unoshandiswa kurwisa utachiona hweura.
4. Furazolidone, se fungicide, ine yakafara antibacterial spectrum.Mabhakitiriya anonyanya kubatwa neEscherichia coli, Bacillus anthracis, paratyphoid rod, Shigella, uye Klebsiella pneumoniae.Salmonella typhi inonzwawo nayo.Inonyanya kushandiswa kurapa zvirwere zvinotapukira-induced dysentery, enteritis, uye cholera.Inogona zvakare kushandiswa kurapa typhoid, paratyphoid, giardiasis, uye trichomoniasis.Kusanganiswa nemishonga inorwisa acid inogona kushandiswa kurapa Helicobacter pylori-induced gastric kuzvimba.Properties: yero poda kana crystalline hupfu, isinganhuhwi, kutanga isingaravike uye yozovava zvishoma;yakanyanya kunyungudika mumvura uye ethanol;inonyungudika zvishoma muchloroform uye isinganyunguriki muether, inonyungudika mudimethylformamide uye nitromethane.Mp: 255 kusvika 259 °C.Kuora panguva yekuparara.
Furazolidone inoshandiswa mugastrointestinal zvirwere uye vaginitis.Inonyanya kushandiswa munyika dzichiri kusimukira kurapa zvirwere zvemanyoka etiology yakasiyana, asi haisi mushonga wekusarudza kana imwe pathogen yakaonekwa.Shandisa sechikamu chechipiri mu giardiasis uye sechikamu chemishonga yakawanda yemishonga muHelicobacter utachiona yakatsigirwa.
3- [(5-Nitrofurylidene) amino] -2-oxazolidinone (Furoxone) inoitika seyero yecrystalline poda ine inovava aftertaste.Haisi kunyungudika mumvura kana doro.Furazolidone ine bactericidal activation inopesana nemhando yakakura yezvirwere zvematumbo, kusanganisira S. aureus, E. coli, Salmonella, Shigella, Proteus spp., Enterobacter, uye Vibrio cholerae.Inoshanda zvakare kurwisa protozoan Giardia lamblia.Inokurudzirwa kurapwa nemuromo kwebhakitiriya kana protozoaldiarrhea inokonzerwa nezvisikwa zvinotapukira.Muyero wevakuru ndeye 100 mg 4 nguva pazuva.
Chikamu chidiki chete chemushonga unopihwa nemuromo wefurazolidoneis wakabatwa.Inenge 5% yemumuromo inoonekwa muweti nenzira yemetabolites yakawanda.Kumwe kunetseka kwepamuviri kwakashumwa nekushandiswa kwayo. Doro rinofanira kudziviswa kana furazolidone iri kushandiswa nokuti mushonga unogona kudzivisa aldehyde dehydrogenase.
