Products

Contusive spinal cord kukuvadzwa kwakaomeswa nekunonoka kurasikirwa kwe oligodendrocytes, zvichikonzera kusingaperi kuenderera kuderera.Naizvozvo, nzira dzekutapurirana dzekupa oligodendrocyte mutsara masero uye kuwedzera huwandu hwemyelination hunoratidzika kunge hwakakodzera kugadzirisa musana.Chidzidzo chemazuva ano chakaongorora kana kuchinjwa kwevanhu neural stem cells (NSCs) genetically modified kuti itaure Olig2 transcript factor, inokosha regulator ye oligodendrocyte development, inogona kuvandudza locomotor recovery uye kuwedzera myelination mune rat contusive spinal cord injury model.HB1.F3 (F3) ) mutsara weNSC wevanhu usingafi wakashandurwa neretroviral vector encoding Olig2, mutongi akakosha wekuvandudza oligodendrocyte.Kuwedzeredza kweOlig2 muNSCs dzevanhu (F3.Olig2) yakakonzera kushandiswa kweNKX2.2 uye yakananga kusiyana kweNSCs mu oligodendrocyte lineage cells in vitro.Nhanganyaya yeOlig2 yakapa basa rekuwedzera, uye nhamba yakakura zvikuru yeF3.Olig2 NSCs yakaonekwa nemavhiki e7 mushure mekusimwa mumusana wakakanganiswa kupfuura wevabereki F3 NSCs.F3.Olig2 NSCs yairatidza kutama nguva zhinji yakananga kunyaya chena, nepo maF3 NSC ainyanya kuvharirwa kune grey matter kana kutenderedza mhango dzemaronda.Zvizhinji zveF3.Olig2 NSCs inobata iyo yakasara chena nyaya inosiyaniswa mune yakakura oligodendrocytes.Transplantation yeF3.Olig2 NSCs yakawedzera huwandu hwechinhu chakasara chena uye yakaderedza huwandu hwemhango.Uyezve, F3.Olig2 magraft akawedzera zvakanyanya kukora kwemyelin sheath yakatenderedza maaxon mune yakachengetedzwa chena nyaya.Pakupedzisira, mhuka dzine F3.Olig2 grafts dzakaratidza kuvandudzwa kwehutano hwehindlimbs locomotion.Transplantation yeNSCs genetically modified kuti iparadzanise mumutsara we oligodendrocytic inogona kuva nzira inobatsira yekuvandudza zvibereko zvekushanda zvinotevera musana wemusana.Chidzidzo chazvino chinoratidza kuti mamorekuru anotonga sarudzo dzemaseru anogona kushandiswa kuti awedzere kugona kwekudzorera kwesero-based therapy.