Glycylglycine Cas: 556-50-3 99% White powder
| Catalog Number | XD90282 |
| Product Name | Glycylglycine |
| CAS | 556-50-3 |
| Molecular Formula | C4H8N2O3 |
| Molecular Weight | 132.11792 |
| Storage Details | Ambient |
| Harmonised Tariff Code | 29241900 |
Chigadzirwa Specification
| Kurasika paKuomesa | <0.2% |
| Sulfate | <0.02% |
| Assay | 99% |
| Mamwe amino acids | Haioneki |
| Transmittance | >95% |
| Chloride | <0.02% |
| Chitarisiko | Hupfu hwakachena kusvika kuchena |
| Simbi (Fe) | <30ppm |
| Heavy Metal (Pb) | <10ppm |
| Ammonium (NH4) | <0.02% |
| Arsenic (as2O3) | <1ppm |
| Residue pakubatidza (se sulphate) | <0.15% |
Carbamoyl phosphate synthetase 1 (CPS1) kushomeka nekuda kweCPS1 mutations ishoma autosomal-recessive urea cycle disorder inokonzeresa hyperammonemia inogona kutungamira kurufu kana kukanganiswa kwetsinga kwakanyanya.CPS1 inokonzeresa carbamoyl phosphate kuumbwa kubva kuammonia, bicarbonate uye maviri mamorekuru eATP, uye inoda allosteric activator N-acetyl-L-glutamate.Kuchinja kwekiriniki kunoitika munharaunda yese yeCPS1 yekukodha, asi kunyanya mumhuri imwechete, pasina kudzokorora.Isu takaratidzira pano iyo chete inozivikanwa parizvino inodzokororwa CPS1 mutation, p.Val1013del, inowanikwa mune gumi nemumwe varwere vasina hukama verudzi rweTurkey vachishandisa recombinant His-tagged wild type kana mutant CPS1 inoratidzwa mubaculovirus/insect cell system.Iyo yepasi rose CPS1 maitiro uye iyo ATPase uye ATP synthesis chikamu maitiro anoratidza, zvichiteerana, bicarbonate uye carbamate phosphorylation matanho, akaedzwa.Takaona kuti CPS1 yemusango mhando uye V1013del mutant yakaratidza kuenzanisa mazinga uye kuchena asi mutant CPS1 yakaratidza hapana zvakakosha zvakasara zviitiko.MuCPS1 structural model, V1013 ndeyepamusoro-soro hydrophobic β-strand pakati pepakati pe β-sheet yeA subdomain ye carbamate phosphorylation domain uye iri pedyo neyakafanotaurwa carbamate tunnel inobatanidza nzvimbo mbiri dzephosphorylation.Zvidzidzo zveHaplotype zvakaratidza kuti p.Val1013del imuvambi mutation.Mukupedzisa, mutation p.V1013del inodzima CPS1 asi haiiti kuti enzyme isanyatsogadzikana kana kusanyungudika.Kudzokororwa kweiyi shanduko chaiyo muvarwere veTurkey ingangove nekuda kweiyo muvambi mhedzisiro, iyo inopindirana neyakajairwa consanguinity inoonekwa muhuwandu hwakabatwa.
