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Kuti ujekese nzira yekutanga ye dentin mineralization, inhibitory effect ye 1-hydroxyethylidene-1,1-bisphosphonate (HEBP) pane dentin mineralization yakaongororwa.Makonzo (100 g) akaiswa pasi pecutaneously neHEBP (8 mg P / kg) ye7 kana 14 d, uye incisors yakagadziriswa Ca histochemistry uye / kana electron microscopy.HEBP-yakarapwa incisors yakaratidza manera-kunge alternate mitsara yemaminerari uye isina-mineralized dentin paapical end.GBHA yakaburitsa zvine mwero mabatiro eCa mune isiri-mineralized circumpulpal denti matrix uko erekitironi maikorosikopu yakaratidza kupararira kwakapfuma kweakanaka mesh-senge erekitironi-dense zvinhu.Non-mineralized mantle dentin matrix yakanga isina kunaka kuCa asi yaive nematrix vesicles (MVs) akawanda akazara necrystalline uye/kana amorphous mineral deposits.Mineralization ye circumpulpal dentin yakaitika yakazvimiririra yeMV-rich mantle denti layer mune zvakakanganisika sampuli.Yedu data inopa histochemical humbowo hwezvinogoneka Ca-binding pfuma ye circumpulpal dentin matrix uye kusavapo kwayo mune mantle dentin uko MV-mediated mineralization inoitika.Mune mantle dentin, HEBP haikanganisi kukura kwekristaro muMVs asi inodzivisa kubuda kwayo mushure mekuputika kwe membrane.Zvinofungidzirwa kuti circumpulpal dentin matrix ine mukana wekuita mineralization yakazvimirira yeMV-mediated mineralization ye mantle dentin, kunyangwe MVs inoona nzvimbo yekutanga uye nguva ye dentin mineralization.