GSSG Cas: 27025-41-8 White crystalline poda
| Catalog Number | XD90229 |
| Product Name | GSSG |
| CAS | 27025-41-8 |
| Molecular Formula | C20H32N6O12S2 |
| Molecular Weight | 612.631 |
| Storage Details | 2 kusvika ku8 °C |
| Harmonised Tariff Code | 2930909899 |
Chigadzirwa Specification
| Kutenderera chaiko | -96 kusvika -106 |
| Heavy metals | 10ppm max |
| AS | 2ppm max |
| Kurasika paKuomesa | 15.0% max. |
| Kuchena | 95% min |
| Residue paIgnition | 0.5% max |
| Chitarisiko | White crystalline powder |
| Assay | 99% |
Hepatotoxicity yevanoda zvinodhaka ndeimwe yezvinonyanya kunetsa mukuongorora zvinodhaka mukutanga kuwanikwa kwezvinodhaka.Kuonekwa kwehepatic oxidative kusagadzikana kunogona kuve chiratidzo chekutanga chehepatotoxicity uye inobatsira kusarudzwa kwezvinodhaka.Iyo glutathione (GSH) uye glutathione disulfide (GSSG) pair, seimwe huru intracellular redox inodzora vakaroorana, inoita basa rakakosha mukudzivirira masero kubva kuoxidative kusagadzikana kunokonzerwa nekusaenzana pakati peprooxidants uye antioxidants.Kugadziriswa kwehuwandu hwehuwandu hweGSSG / GSH uye huwandu hweGSH uye GSSG hwakashandiswa kuratidza kushushikana kweiyo oxidative mumaseru nematishu.Muchidzidzo ichi, takaedza mukana wekushandisa iyo biliary GSSG/GSH ratios sebiomarker kuratidza hepatic oxidative kusagadzikana uye huturu hwezvinodhaka.Makomisheni mana anozivikanwa kushandura mazinga eGSH neGSSG akaedzwa muchidzidzo ichi.Diquat (diquat dibromide monohydrate) uye acetaminophen zvakapiwa makonzo.Paraquat uye tert-butyl hydroperoxide yaipihwa d kumakonzo kuti iite shanduko yebiliary GSH uye GSSG.Iyo biliary GSH uye GSSG yakaverengerwa pachishandiswa calibration macurves akagadzirwa neartificial bile kuti azvidavirire kune chero bile matrix mhedzisiro muLC-MS kuongororwa uye kudzivirira kukanganiswa kweendogenous GSH neGSSG.Nemienzaniso mina (mumakonzo nemakonzo) yekuchinja-kunokonzerwa nezvinodhaka mukinetics yebiliary GSSG/GSH ratios, chidzidzo ichi chakaratidza mukana wekugadzira index exposure response based based on biliary GSSG/GSH ratios yekufanotaura hepatic oxidative stress.
