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Guanosine analogues akati wandei, kureva acyclovir (uye prodrug yayo yemuromo valaciclovir), penciclovir (muneoral prodrug form, famciclovir) uye ganciclovir, anoshandiswa zvakanyanya kurapa herpesvirus [kureva herpes simplex virus type 1 (HSV-1), uye mhando. 2 (HSV-2), varicella-zoster virus (VZV) uye/kana human cytomegalovirus (HCMV)] zvirwere.Mumakore achangopfuura, akati wandei maguanosine analogues akagadzirwa, anosanganisira matatu-membered cyclopropylmethyl uye -methenyl derivatives (A-5021 uye synguanol) uye 6-nhengo D- uye L-cyclohexenyl zvinobva.Chiitiko cheacyclic/carbocyclic guanosine analogues chakatemerwa kurwisa huwandu hwakawanda hwehutachiona, hunosanganisira HSV-1, HSV-2, VZV, HCMV, uye zvakare vanhu herpesviruses Type 6 (HHV-6), mhando 7 (HHV- 7) uye mhando 8 (HHV-8), uye utachiona hwehepatitis B (HBV).Iyo itsva guanosine analogues (kureva A-5021 uye D- uye L-cyclohexenyl G) yakawanikwa ichinyanya kushanda kurwisa iwo mavhairasi (HSV-1, HSV-2, VZV) ayo encode kune chaiyo thymidine kinase (TK), ichikurudzira. kuti basa ravo rekudzivirira hutachiona (zvishoma zvishoma) zvinoenderana nephosphorylation nehutachiona-induced TK.Yakanyorwa antiviral chiitiko chakacherechedzwa zvakare neA-5021 inopesana neHHV-6 uye ine D- uye L-cyclohexenyl G inopesana neHCMV neHBV.Iyo antiviral chiitiko cheacyclic/carbocyclic nucleoside analogues inogona kugoneswa zvakanyanya ne mycophenolic acid, inhibitor ine simba yeinosine 5'-monophosphate (IMP) dehydrogenase.Iyo itsva carbocyclic guanosine analogues (kureva A-5021 uye D- uye L-cyclohexenyl G) inobata chivimbiso chikuru, kwete chete semishonga inorwisa mavhairasi pakurapa kweherpesvirus utachiona, asiwo antitumor agents emusanganiswa gene therapy/chemotherapy yegomarara, kunze kwekuti (chikamu che) masero ebundu akashandurwa nehutachiona (HSV-1, VZV) TK gene.