Heparin sodium Cas:9041-08-1 chena kana inenge yakachena, hygroscopic powder
| Catalog Number | XD90184 |
| Product Name | Heparin sodium |
| CAS | 9041-08-1 |
| Molecular Formula | C12H17NO20S3 |
| Molecular Weight | 591.45 |
| Storage Details | 2 kusvika ku8 °C |
| Harmonised Tariff Code | 30019091 |
Chigadzirwa Specification
| Chitarisiko | chena kana inenge yakachena, hygroscopic powder |
| Assay | 99% |
| Kutenderera chaiko | Dry goods haifaniri kunge iri pasi pe +50 ° |
| pH | 5.5 - 8.0 |
| Bacterial endotoxin | Isingasviki 0.01 IU paInternational Unit yeheparin |
| Residual solvent | Zvinoenderana neyemukati mwero nzira ine peak nzvimbo kuverenga, methanol, ethanol, acetone, uye, zvakare, 0.3%, 0.5%, kana zvishoma. |
| Residue paIgnition | 28.0% -41.0% |
| Sodium | 10.5% -13.5% (yakaomeswa zvinhu) |
| Mapuroteni | <0.5% (yakaomeswa zvinhu) |
| Nitrogen | 1.3% -2.5% (yakaomeswa zvinhu) |
| Nucleotidic Impurities | 260nm <0.10 |
| Simbi inorema | ≤ 30ppm |
| Kujeka uye ruvara rwemhinduro | Solution inofanira kuva yakajeka isina ruvara;Zvakadai se turbidity, ultraviolet-visible spectrophotometry, kutsunga kwekutora pamhepo ye640 nm, haifaniri kudarika 0.018;Zvakadai seruvara, zvichienzaniswa neyakajairwa colorimetric liquid yero, haifanirwe kudzika |
| Related Substance | Sum of dermatan sulfate uye chondroitin sulphate: kwete kupfuura aera inoenderana peak muchomatogram yakawanikwa nereferensi mhinduro.Chero humwe hutsvina: hapana nhongonya kunze kwepamusoro nekuda kwe determatan sulfate uye chondroitin sulfate inowanikwa. |
| anti-FXa/anti-FIIa | 0.9-1.1 |
| Liquid chromatography | Kudzora mhinduro yemuenzaniso muchromatogram, dermatan sulfate (kureba kwepamusoro uye heparin uye dermatan sulfate) pakati peak mupata kureba reshiyo haingasviki 1.3, inowanikwa nebvunzo mhinduro yakafanana mukuchengetedza nguva uye chimiro kune chikuru peak muchromatogram yakawanikwa ne referensi mhinduro.Kurevesa nguva yekukanganisa kwakasiyana hakufaniri kudarika 5% |
| Molecular weight uye molecular weight distribution | Huremu hwepakati molecular uremu hunofanira kunge huri 15000 - 19000. Huremu hwemamorekuru hunopfuura 24000 yegiredhi haifanire kunge yakakura kupfuura 20%, iyo molecular uremu hwe8000 - 16000 yehuremu hwe24000 - 16000 yereshiyo haifanirwe kuve shoma. kupfuura 1 |
| yakaoma uremu kurasikirwa | ≤ 5.0% |
| Micro organisms | Yese inoshanda aerobic kuverenga: <10³cfu/g.Fungi/mbiriso <10²cfu/g |
| anti-factor IIa | ≥180 IU/mg |
Heparin, Sodium munyu iheparin polymer inoburitsa yakakura anticoagulant mhedzisiro ne activate antithrombin.Iyi activation inokonzeresa shanduko muATIII uye inobvumira kuwedzera kuchinjika mune yayo reactive saiti loop.Heparin inonyanya sulfated glycosaminoglycan inozivikanwa nekudzivirira kugwamba.Heparin, Sodium Munyu zvakare activator yeRyR uye ATIII.
Zvenyama uye zvemakemikari zvimiro: Heparin sodium ichena kana inenge chena hupfu, isinganhuhwi, hygroscopic, inonyungudika mumvura, isinganyungudika muorganic solvents senge ethanol uye acetone.Iine simba rakashata rakaipa mune aqueous solution uye inogona kusanganisa nemamwe macations kuti igadzire ma molecular complexes.Aqueous solutions akanyanya kugadzikana pa pH 7.
Anticoagulant: Heparin sodium is anticoagulant, mucopolysaccharide, iyo sodium munyu weglucosamine sulfate inotorwa kubva mudumbu remukati menguruve, mombe nemakwai, uye inovanzwa nemaseru maseru mumuviri wemunhu.Uye zvinongowanikwa muropa.Heparin sodium ine mabasa ekudzivirira kuunganidzwa kweplatelet uye kuparadzwa, kurambidza kutendeuka kwefibrinogen kuita fibrin monomer, kurambidza kuumbwa kwethromboplastin uye kuramba kuumbwa kwethromboplastin, kudzivirira kutendeuka kweprothrombin kuita thrombin uye antithrombin.Heparin sodium inogona kunonoka kana kudzivirira ropa coagulation zvese mu vitro uye mu vivo.Maitiro ayo ekuita akaomesesa zvakanyanya uye anokanganisa akawanda malink mukuita coagulation.Mabasa ayo ndeaya: ① inhibit kuumbwa uye kushanda kwethromboplastin, nokudaro kudzivirira prothrombin kubva pakuva thrombin;②mumatunhu akakwirira, ane mhedzisiro yekuvharisa thrombin nezvimwe zvinhu coagulation, kudzivirira fibrinogen kubva pakuva fibrin Protein;③ inogona kudzivirira kuunganidzwa uye kuparadzwa kweplatelet.Mukuwedzera, iyo anticoagulant mhedzisiro yeheparin sodium ichiri kuenderana neiyo yakaipa chaja sulfate radical mumorekuru wayo.Positively charged alkaline substances senge protamine kana toluidine blue inogona kudzikamisa chaji yayo isina kunaka, saka inogona kuvharidzira anticoagulation yayo.effect.Nekuti heparin inogona kumisa uye kuburitsa lipoprotein lipase mu vivo, hydrolyze triglyceride uye yakaderera-density lipoprotein ye chylomicrons, saka ine zvakare hypolipidemic athari.Heparin sodium inogona kushandiswa kurapa acute thromboembolic chirwere, kuparadzirwa intravascular coagulation (DIC).Mumakore achangopfuura, heparin yakawanikwa iine mhedzisiro yekubvisa ropa lipids.Jekiseni remutsinga kana jekiseni rakadzika remumuscular (kana jekiseni rezasi), 5,000 kusvika 10,000 mayunitsi nguva imwe neimwe.Heparin sodium haina muchetura uye inongoerekana yabuda ropa ndiyo njodzi inonyanya kukosha yeheparin overdose.Isingashande nemuromo, inofanirwa kupihwa nejekiseni.Intramuscular jekiseni kana subcutaneous jekiseni rinonyanya kutsamwisa, dzimwe nguva allergic reactions inogona kuitika, uye overdose inogona kutokonzera kusungwa kwemwoyo;dzimwe nguva kupera kwebvudzi kwenguva pfupi uye manyoka.Mukuwedzera, inogona kuramba ichikonzera kuputsika kwepamuviri.Kushandiswa kwenguva refu dzimwe nguva kunogona kukonzera thrombosis, iyo inogona kunge iri mhedzisiro yeanticoagulase-III kupera.Heparin sodium inopesana nevarwere vane tsika yekubuda ropa, chiropa chakanyanya uye kusakwana kwerenal, hypertension yakanyanya, hemophilia, intracranial hemorrhage, peptic ulcer, vakadzi vane pamuviri uye postpartum, visceral tumors, trauma uye kuvhiyiwa.
Zvishandiso: Tsvakurudzo yeBiochemical, inoshandiswa kudzivirira kutendeuka kweprothrombin kuita thrombin, ine antithrombotic effect.
Zvishandiso: Heparin sodium is mucopolysaccharide biochemical drug yakatorwa kubva kune porcine intestinal mucosa ine yakasimba anticoagulant basa.Mclcan akawana femoral mucopolysaccharide heparin munyama yechiropa kubva kumbwa achidzidza magadzirirwo eropa.Brinkous et al.yakaratidza kuti heparin ine anticoagulant basa.Mushure mekunge heparin yakashandiswa se anticoagulant mumakiriniki ekushandiswa kwekutanga, yakagamuchira kutarisa kubva kumativi ose enyika.Kunyange zvazvo ine nhoroondo yemakore anopfuura 60 mukushandiswa kwekliniki, hapana chigadzirwa chinogona kutsiva zvachose kusvika ikozvino, saka ichiri chimwe chezvinonyanya kukosha anticoagulant uye antithrombotic biochemical drugs.Iine huwandu hwakawanda hwekushandisa mukurapa.Inoshandiswa kurapa acute myocardial infarction uye pathogenic hepatitis.Inogona kushandiswa pamwe chete ne ribonucleic acid kuti iwedzere kushanda kwehepatitis B. Inogona kushandiswa pamwe chete nekemotherapy kudzivirira thrombosis.Inogona kuderedza lipids yeropa uye kuvandudza basa remuviri wemunhu.inewo chimwe mhedzisiro.Yakaderera molecular uremu heparin sodium ine anticoagulant factor Xa chiitiko.Zvidzidzo zvePharmacodynamic zvakaratidza kuti yakaderera molecular uremu heparin sodium ine inhibitory mhedzisiro pakuumbwa kwethrombus uye arteriovenous thrombosis mu vivo uye in vitro, asi ine zvishoma zvinokanganisa coagulation uye fibrinolysis system, zvichikonzera antithrombotic athari.kubuda ropa kunenge kushoma.Unfractionated heparin musanganiswa weakasiyana-siyana amino glucan glycosides anogona kunonoka kana kudzivirira ropa coagulation zvese in vitro uye in vivo.Its anticoagulation mechanism yakaoma, uye ine mhedzisiro pane ese maficha ekubatana.Kusanganisira inhibition yeprothrombin mu thrombin;inhibition ye thrombin basa;kutadzisa kushandurwa kwefibrinogen kuita fibrin;kudzivirira kuunganidzwa kweplatelet uye kuparadzwa.Heparin inogona kuramba ichidzikisa lipids yeropa, yakaderera LDL uye VLDL, kuwedzera HDL, kushandura viscosity yeropa, kudzivirira vascular endothelial masero, kudzivirira atherosclerosis, kukurudzira kuyerera kweropa, uye kugadzirisa coronary kutenderera.
Zvishandiso: Biochemical research, kudzivirira kutendeuka kweprothrombin kuita thrombin.
Zvishandiso: Inoshandiswa kunonoka uye kudzivirira kugwamba kweropa
