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Kudzokororwa kweABL1 gene kuenda kuBCR gene kunoguma nekutaura kweiyo oncogenic BCR-ABL1 fusion protein, iyo inotaridza munhu asingaperi myeloid leukemia (CML), myeloproliferative disorder inoonekwa seinouraya nguva dzose kusvika pakatangwa mhuri yeimatinib yetyrosine kinase. inhibitors (TKI).Zvakadaro, kusanzwa kweCML stem masero kuTKI kurapwa uye mukati kana kuwana kuramba zvichiri zvikonzero zvinowanzoitika zvekuramba kwechirwere uye blastic phase progression inowanikwa muvarwere mushure mekutanga kurapa kwakabudirira.Pano, takaongorora basa rinobvira reMAPK15/ERK8 kinase muBCR-ABL1-inotsamira autophagy, chirongwa chakakosha cheoncogene-induced leukemogenesis.Muchirevo chechinyorwa chino, isu takaratidza kugona kweMAPK15 kunotora iyo oncogene kune autophagic vesicles, tichisimbisa fungidziro yedu yebasa rakakosha reiyi MAP kinase mukufambiswa kwechiratidzo neiyi oncogene.Chokwadi, nekuenzanisa BCR-ABL1 kusaina mumaseru eHeLa uye nekutora mukana weiyo physiologically inoenderana neCML yemunhu, kureva maseru eK562, takaratidza kuti BCR-ABL1-induced autophagy inorevererwa neMAPK15 kuburikidza nekugona kwayo kudyidzana neLC3-mhuri. mapuroteni, nenzira inoenderana neLIR.Sezvineiwo, isu takakwanisawo kupindira neBCR-ABL1-induced autophagy nenzira yemishonga ine chinangwa chekuvharisa MAPK15, kuvhura mukana wekuita pane iyi kinase kukanganisa autophagy uye zvirwere zvinoenderana nebasa iri cellular.Chokwadi, kutsigira kuitika kweiyi nzira, takaratidza kuti kupera kwe endo native MAPK15 kutaura kwakadzivirira BCR-ABL1-inotsamira sero kuwanda, in vitro, uye kuumbwa kwebundu, in vivo, saka ichipa chinyorwa "chinodhaka" pakati peBCR-ABL1 uye. CML yevanhu.