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Ivermectin (Cardomec, Eqvalan, Ivomec) musanganiswa we22,23-dihydro derivatives yeavermectins B1a uye B1byakagadzirirwa necatalytic hydrogenation.Avermectins inhengo dzemhuri yemishonga inorwisa mabhakitiriya yakaoma inogadzirwa nekuvirisa nerudzi rweStreptomycesavermitilis.Kuwanikwa kwavo kwakaguma nekuongororwa kwakasimba kwetsika dzeanthelmintic agents kubva kune zvakasikwa.Ivermectin inoshanda mune yakaderera dosage inopesana nemhando dzakasiyana dzenematodes uye arthropods iyo parasitizemhuka.
Ivermectin yakawana kushandiswa kwakapararira mukurapa kwezvipfuyo muUnited States uye nyika zhinji pasi rese kudzora endoparasites uye ectoparasitesin mhuka dzemumba.Yakawanikwa ichishanda pakurapa onchocerciasis ("kupofumadza kwerwizi") muvanhu, hosha yakakosha inokonzerwa negonye reroundwormOncocerca volvulus, rinopararira kuMadokero neCentral Africa, Middle East, uye South uye Central America. Ivermectin inoparadza microfilariae, immature mafomu emanematode, ayo anogadzira ganda nemanodule ematishu anoratidza kubatwa uye anogona kutungamira kuupofu. Inodzivirira kuburitswa kwemicrofilariae nemakonye akura anogara munharaunda.Zvidzidzo pamusoro pemagadzirirwo ekuita kweivermectin zvinoratidza kuti inovharira kutapurirana kweinterneuron-motor neuron mumanematodes nekukurudzira kuburitswa kweGABA inodzivirira neurotransmitter. Mushonga uyu wakaitwa kuti uwanikwe nemugadziri maererano nerubatsiro kuzvirongwa zvekurapa zvinoenderana neWorld Health Organisation.

Ivermectin ine-broad-spectrum activity pakuti inogona kukanganisa nematodes, zvipembenene, uye acarine parasites.Ndiwo mushonga wesarudzo mune onchocerciasis uye unobatsira chaizvo pakurapa mamwe marudzi efilariasis, strongyloidiasis, ascariasis, loiasis, uye cutaneous larva migrans.Inoshanda zvakanyanya kurwisa mite dzakasiyana siyana.Ndiwo mushonga wesarudzo mukurapa vanhu vane utachiona hweOnchocerca volvulus, uchiita semushonga wemicrofilaricidal uchirwisa makonye anogara paganda (microfilaria).Kurapa kwegore negore kunogona kudzivirira upofu kubva kune ocular onchocerciasis.Ivermectin inonyatsoshanda kupfuura diethylcarbamazine mu bancroftian filariasis, uye inoderedza microfilaremia kusvika pedyo ne zero mazinga.Mubrugian filariasis diethylcarbamazine-induced clearance inogona kunge iri nani.Inoshandiswawo kurapa cutaneous larva migrans uye kuparadzira strongyloidiasis.Kushandiswa kwaro kwakachengeteka pamuviri hakusati kwasimbiswa zvizere.