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1.Early T-cell precursor leukemia (ETP-ALL) i-high-risk subtype ye leukemia yevanhu iyo inonyatsonzwisiswa pahutano hwema molecular.Pano tinoshuma mafambiro akananga zinc chigunwe E-box-binding transcription factor ZEB2 seyakadzokororwa genetic lesion mu immature/ETP-ALL.Tichishandisa mamiriro ekuwana-we-kushanda mbeva modhi, tinoratidza kuti yakasimbiswa Zeb2 kutaura kunotanga T-cell leukemia.Uyezve, Zeb2-inotyairwa mbeva leukemia inoratidza mamwe maficha emunhu asati akura/ETP-ALL gene kutaura siginicha, pamwe neyakagadziridzwa leukemia-kutanga kugona uye yakagadziriswa Janus kinase (JAK)/signal transducer uye activators of transcript (STAT) kusaina kuburikidza. transcriptional activation yeIL7R.Chidzidzo ichi chinoburitsa ZEB2 seoncogene mubiology yevasina kukura/ETP-ALL uye inovhura nzira inoenda kuzvidzidzo zvepamberi zvekiriniki zvemakomponi matsva ekurapwa kweiyi hukasha subtype yemunhu T-ALL tichishandisa yedu Zeb2 inotyairwa mbeva modhi.

2.Pluripotency, kuzvivandudza, uye kusiyanisa zvinhu zvakakosha zve embryonic stem (ES) masero, nokudaro kupa maonero anokosha mumishonga yekudzorera.Mafambiro ebudiriro anoda sangano rakanyatsorongeka, rinonyanya kudzorwa neanozivikanwa JAK/STAT, PI3K/AKT, uye ERK/MAPK nzira.SPREDs (Sprouty related proteins neEVH1 domain) yakawanikwa se inhibitors yeERK / MAPK yechiratidzo nzira, asi hapana chaizivikanwa pamusoro pemabasa avo mumasero eES uye panguva yekusiyanisa kwepakutanga, kusvika ikozvino.Takagadzira SPRED1 uye SPRED2 overexpressing uye SPRED2 knockout murine ES masero kuti aongorore mashandiro eSPRED mapuroteni muES masero uye panguva yekutanga kusiyanisa.Kuwedzeredza kweSPREDs kunowedzera zvakanyanya kuzvidzora uye clonogenicity yemurine ES masero, asi kushayikwa kweSPRED2 kunoderedza kupararira uye kuwedzera apoptosis.Munguva yekutanga kusiyanisa mumiviri ye embryoid, SPREDs inosimudzira iyo pluripotent state uye inodzivisa kusiyanisa uko mesodermal d ifferentiation mu cardiomyocytes inononoka uye inovharwa.LIF- uye kukura factor-stimulation kwakaratidza kuti SPREDs inhibit ERK/MAPK activation mumurine ES masero.Zvisinei, hapana migumisiro yakaonekwa paLIF-induced activation yeJAK / STAT3, kana PI3K / AKT yechiratidzo nzira neSPRED mapuroteni.Tinoratidza kuti SPREDs inokurudzira kuzvivandudza uye inhibit mesodermal kusiyana kwemurine ES masero nekusarudzwa kudzvinyirirwa kweERK / MAPK yekusaina nzira mumaseru epluripotent.