L-Histidine Cas: 71-00-1 98.5% Makristasi machena kana crystalline poda
| Catalog Number | XD90301 |
| Product Name | L-Histidine |
| CAS | 71-00-1 |
| Molecular Formula | C6H9N3O2 |
| Molecular Weight | 155.15 |
| Storage Details | Ambient |
| Harmonised Tariff Code | 29332990 |
Chigadzirwa Specification
| Assay | 98.5% min |
| Chitarisiko | Makristasi machena kana crystalline poda |
| Giredhi | USP39 |
| Kutenderera chaiko | +12.6 ° kusvika +14.0 ° |
| Identification | Infrared absorption |
| pH | 7.0 - 8.5 |
| SO4 | <=0.03% |
| Fe | <=30ppm |
| Kurasika paKuomesa | <=0.2% |
| Residue paIgnition | <=0.1% |
| Cl | <=0.05% |
| Heavy metal (PB) | <=15ppm |
| Related compones | Kwete kupfuura 0.5% yehupi hupi husina kuchena hunowanikwa;Kwete kupfuura 2.0% yetsvina yese inowanikwa |
iye quadruplex achigadzira G-rich sequences akagoverwa zvisina kuenzana mukati mejenome remunhu.Kupfumisa kwavo muvanosimudzira oncogenic uye telomeres kwaunza kufarira kunanga G-quadruplex (GQ) yekurapa anticancer.Pano, isu tinopa ongororo yehuwandu pane conformations uye dynamics yeGQ kugadzira sequence kuyerwa ne single molecule fluorescence.Pamusoro pezvo, tinofananidza zvivakwa izvi kuGQ yakanangana ne ligands uye G4 resolvase 1 (G4R1) protein inosunga.Mhedzisiro yedu inoratidza kuti ese ari maviri loop (asiri-G zvikamu) kureba uye kutevedzana kunobatsira pakuumbwa kweGQ.Real time single molecule traces inoratidza kuti kupeta dynamics zvakare kunoenderana nekuumbwa kwe loop.Isu tinoratidza kuti GQ-inodzikamisa mamorekuru madiki, N-methyl mesoporphyrin IX (NMM), analogi yayo, NMP uye G4R1 protein inosunga zvakasarudzwa kune yakafanana GQ conformation.Zvatinowana zvinonongedza kuomarara kweGQ kupeta kunotongwa nehurefu hwelop uye kutevedzana uye kuti iyo GQ conformation inosarudza sei diki molecule uye protein inosunga propensity.
