L-Ornithine L-Aspartate Cas:3230-94-2
| Catalog Number | XD91158 |
| Product Name | L-Ornithine L-Aspartate |
| CAS | 3230-94-2 |
| Molecular Formula | C9H19N3O6 |
| Molecular Weight | 265.26 |
| Storage Details | 2 kusvika ku8 °C |
| Harmonised Tariff Code | 29224985 |
Chigadzirwa Specification
| Chitarisiko | White crystalline powder |
| Assay | >99% |
| Kutenderera chaiko | +27 +/-1 |
| Heavy metals | <0.001% |
| pH | 6 - 7 |
| Kurasika paKuomesa | <7% |
| Residue paIgnition | <0.2% |
| State of Solution | Zvakajeka |
Ornithine aspartate ndiyo yekutanga kiriniki yakashandiswa mukurapa hangover uye hepatic encephalopathy.Nekuunganidzwa kwechiitiko chekiriniki yekushandisa, ornithine aspartate yakashandiswa zvakanyanya mukurapa kwezvirwere zvechiropa, uye yakawana chaiyo yekurapa mhedzisiro pahepatic encephalopathy, kukuvara kwechiropa kunokonzerwa nezvinodhaka, chiropa chine mafuta, chisingaperi hepatitis nezvimwe zvirwere, zvave zvakanyanya. zvinozivikanwa nevarapi.
Ornithine aspartate inopa substrate ye urea uye glutamine synthesis mu vivo.Glutamine ndiyo detoxification chigadzirwa cheammonia, pamwe nekuchengetedza uye nzira yekufambisa yeammonia.Pasi pemamiriro ehupenyu uye pathological, iyo synthesis ye urea uye synthesis ye glutamine inobatwa ne ornithine, aspartic acid uye mamwe dicarboxyl makomisheni.Ornithine inobatanidzwa mune inenge yose maitiro ekushandiswa kweiyo urea cycle uye detoxification yeammonia.Arginine inoumbwa panguva iyi, uye urea inobva yaparadzaniswa kuita ornithine.Aspartic acid inobatanidzwa mukugadzirwa kwe nucleic acid mu hepatocytes kuti iite kuti kugadziriswa kwehepatocytes yakakuvadzwa.Pamusoro pezvo, nekuda kwekusimudzira kusiri kwakananga kweaspartic acid pane metabolic process ye tricarboxylic acid kutenderera mumasero echiropa, inosimudzira synthesis yesimba mumaseru echiropa, ayo anobatsira kugadziridzwa kweakakuvadzwa maseru echiropa uye nekukurumidza kudzoreredza kwechiropa kushanda.Kufambira mberi kwemazuva ano kwakaratidza kuti aspartate inogonawo kudzivisa basa re inflammasomes kuburikidza neN-methyl-D-aspartate (NMDA) receptors, nokudaro kuderedza nzira yemishonga yekupindura kwechiropa.NMDA receptors imhando yeionotropic excitatory glutamate receptors, iyo inoita basa rakakosha mune zvemuviri maitiro senge synaptic transmission, synaptic plasticity, kudzidza uye ndangariro mupakati tsinga system.Zvidzidzo zvepathological zvinotevera zvakasimbisawo kuti aspartate yakavandudza zvakanyanya maronda ekuzvimba muchiropa.
Clinical application
Mumunda wechirwere chechiropa: Ornithine aspartate inoshandiswa zvakanyanya semishonga inorwisa-kupisa uye hepatoprotective mukurapa zvirwere zvakasiyana-siyana zvechiropa, zvakadai sehepatic encephalopathy, chiropa chinokonzerwa nemishonga, chiropa chemafuta, chirwere chisingaperi chehepatitis, nezvimwewo. ropa ammonia muvarwere vane encephalopathy uye kusunungurwa kwezviratidzo zveurouropsychiatric zvishoma nezvishoma zvinova mushonga mukuru wekurapa wekurapa zvirwere zvakasiyana-siyana zvechiropa.
Ornithine aspartate inokosha substrate ye synthesis ye urea uye glutamine.Ornithine inogona kumisa ma enzymes akakosha mukuita kwe urea synthesis - ornithine carbamoyltransferase uye carbamoyl phosphate synthase, uye kusimudzira ammonia Metabolism kuti iwane detoxification yeropa ammonia, aspartic acid se substrate inogona kuburitsa glutamic acid uye oxaloacetic acid, detoxification ndiyo chigadzirwa che glutamine. ammonia, uye iri zvakare kuchengetedza uye kutakura kweammonia.Oxaloacetate inotora chikamu mu tricarboxylic acid cycle, inosimudzira kugadzirwa kwesimba mumasero echiropa, uye inoita kuti masero echiropa akakuvadzwa agadziriswe, agadziriswe, uye adzorerwe kushanda kwechiropa.Ornithine aspartate inogona kunyatso kuvandudza kushanda kwechiropa, kuderedza ropa ammonia, uye synergistically kuderedza ammonia ne lactulose uye ofloxacin, nokudaro kuvandudza zvakanyanya kurapa kwehepatic encephalopathy, iyo yakakodzera kushandiswa kwekliniki.
Oncology: Nekuchinja kunoramba kuripo mumhando uye madosi emishonga yechemotherapy, matambudziko ane chekuita nechemotherapy mishonga ari kubuda zvakare, uye kukuvara kwechiropa ndeimwe yezvinowanzo kuvadza nhengo.Kana kukuvara kwechiropa kuchinge kwaitika, zvinokanganisa hutano hwemuviri uye hwepfungwa hwevarwere kune madhigirii akasiyana, kutadzisa kuitwa kwechemotherapy regimens, uye kunetesa kurapa kwechemotherapy.Muzviitiko zvakakomba, kusashanda kwechiropa kunogona kutyisa upenyu.Ornithine aspartate inogona kuvandudza zvakanyanya kukuvara kwechiropa kunokonzerwa nechemotherapy mishonga uye kugadzirisa kurapa kwevarwere vebundu.
Munda wekuvhiya: Kuvhiya kurova kunhengo dzemuviri wese wemurwere, uye kukuvara kwechiropa mushure mekushanda idambudziko rinowanzoitika.Ornithine aspartate inogona kudzivirira uye kubata postoperative kukuvara kwechiropa uye kukurudzira postoperative kupora kwevarwere.
