N-(2-Acetamide)iminodiacetic acid Cas: 26239-55-4 99% White powder
| Catalog Number | XD90194 |
| Product Name | ADA (N-(-2-Acetamido)iminodiacetic acid) |
| CAS | 26239-55-4 |
| Molecular Formula | C6H10N2O5 |
| Molecular Weight | 190.15 |
| Storage Details | Ambient |
| Harmonised Tariff Code | 29241900 |
Chigadzirwa Specification
| Fe | <5ppm |
| Pb | <5ppm |
| Kurasika paKuomesa | <0.5% |
| Sulfated ash | <0.1% |
| Chitarisiko | Upfu chena |
| Zvimwe Zvinonyungudutsa | Hapana |
| Nguva Yekuparara (9g mu91ml 1M NaOH, Magnetic Kukurudzira) | <1min |
| A300 ( 9% mu1 M NaOH) | <0.08% |
| Nhamba yemagumo Inocherechedzwa muine titration curve | Vaviri chete |
| pH Range inotsanangura iyo Titration Yechipiri Endpoint | 9.1 - 10.1 |
| Solubility (9% mu1M NaOH) | Zvakajeka uye Zvisina Ruvara |
| Zuva rekugadzira | |
| Mvura KF | <1% |
| Assay (Titration) pane yakaomeswa hwaro | >99.0% |
| Infrared | Zvinoenderana |
Iyo nucleoside adenosine inoshanda panheyo uye yemwoyo masisitimu kuburikidza neA2A receptor (A2AR).Mukupindura kumazinga eokisijeni mumatissue, adenosine plasma concentration inodzorwa kunyanya kuburikidza neiyo synthesis neCD73 uye kuburikidza nekuderedzwa kwayo neadenosine deaminase (ADA).Iyo cell-surface endopeptidase CD26 inodzora kuwanda kwevasoactive uye antioxidant peptides uye nekudaro inogadzirisa kupihwa kweokisijeni kumatishu uye oxidative kusagadzikana mhinduro.Kunyangwe kuwandisa kweadenosine, CD73, ADA, A2AR, uye CD26 mukupindura hypoxia kwakanyatso kunyorwa, mhedzisiro ye hyperoxic uye hyperbaric mamiriro pazvinhu izvi anofanirwa kutariswa zvakare.Rats uye murine Chem-3 cell line iyo inoratidzira A2AR yakaratidzirwa ku 0.21 bar O2, 0.79 bar N2 (mamiriro epasi; normoxia);1 bar O2 (hyperoxia);2 bar O2 (hyperbaric hyperoxia);0.21 bhaa O2, 1.79 bhaa N2 (hyperbaria).Adenosine plasma concentration, CD73, ADA, A2AR kutaura, uye CD26 chiitiko chakatariswa mu vivo, uye kugadzirwa kwekampu kwakatariswa mu cellulo.Nokuti mumamiriro ezvinhu, 1) hyperoxia yakaderera adenosine plasma level uye T cell surface CD26 basa, asi yakawedzera CD73 kutaura uye ADA level;2) hyperbaric hyperoxia yaida kuwedzera maitiro;uye 3) hyperbaria chete yakanga isina simba guru pamiganhu iyi.Muuropi uye mu cellulo, 1) hyperoxia yakaderera kutaura kweA2AR;2) hyperbaric hyperoxia yakawedzera maitiro;uye 3) hyperbaria chete yakaratidza simba rakasimba.Takawana muenzaniso wakafanana maererano nezvose A2AR mRNA synthesis muuropi uye kugadzirwa kwekampu muChem-3 masero.Saka iyo yakakwira okisijeni level yaiwanzo kudzikisa iyo adenosinergic nzira uye CD26 chiitiko.Hyperbaria chete yakabata chete A2AR kutaura uye kugadzirwa kwekampu.Isu tinokurukura kuti nzira dzakadai dzinokonzereswa ne hyperoxygenation dzinogona kudzikamisa sei, kuburikidza ne vasoconstriction, iyo oksijeni inopa kune tishu uye kugadzirwa kweanoshanda oksijeni marudzi.
