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Neocuproine reagent is reagent yemhangura yekutsunga, chena kana yero-brown crystal, inogumbura.Inonyanya kushandiswa se reagent yekutsunga kwe cuprous, photometric kutsunga kwemhangura, kutsunga kwe-ultra-micro shuga yeropa;organic synthesis.Neocuproine hydrochloride monohydrate yakashandiswa mukuyera kunyungudika kwemhangura muCu–Ni alloys uchishandisa nzira yecolorimetric.Yakashandiswawo mukugadzirira yakaoma agent mhinduro mukudzidza iyo antioxidant masimba assays mune biological samples yakavakirwa paCu kuderedza makomba.Inogona kushandiswa seyakatangira kugadzirira neocuproine, inoshandiswa seanoongorora reagent yekutemerwa kwemhangura mumasampuli ezvakatipoteredza uchishandisa spectrophotometric tekinoroji.

Zvichakadaro, mushonga wakadaro une mashandisirwo akasiyana mukurapa. Munguva pfupi yapfuura, Eribulin yakabvumidzwa kutengeswa neNational Medical Products Administration (NMPA) yenyika yangu kuti irapwe varwere vekenza yemazamu inowanzoitika kana yemetastatic avo vakagamuchira kanenge kaviri chemotherapy. mitemo (kusanganisira anthracyclines uye taxans) munguva yakapfuura.Yakaunza nzira nyowani yekurapa kumunda wekenza yemazamu chemotherapy muChina, Inounzawo dzimwe nzira dzekurapa dzevarwere.
Eribulin isiri-taxane tubulin inhibitor.Kusiyana ne taxane uye vinblastine tubulin inhibitors, Eribulin ine nzira yakakosha yekuita, iyo inoita kuti Eribulin Ichiri kushanda kune varwere mushure mekudzivirira zvinodhaka kune yew;Eribulin inewo isiri-cytotoxic migumisiro, kusanganisira vascular remodeling, kuwedzera kusvibiswa kwemamwe madhiragi mu tumor microenvironment, synergizing mamwe madhiragi, uye kudzorera masero emamota The epidermal-mesenchymal transition nezvimwe zvakadaro.

Kubva pakusanganiswa kwehalichondrin B, kushandiswa kwemhangura itsva reagents sepakati, kusvika pakugadziriswa kweEribulin, kusvika kukugadzirwa kwemaindasitiri eEribulin, masayendisiti kubva kumakambani ezvidzidzo nemishonga akapedza makore anopfuura 20 ekuongorora.Zvigadzirwa zvechisikigo zvinobva mugungwa zvave mishonga inogona kurapa gomarara.Tsvagiridzo uye kusimudzira kweEribulin imhaka yekuti iyo nyowani yemhangura reagent inonyanya kukosha seyakanyanya yepakati yeAPI yayo.Iyo nyowani yemhangura reagent ine basa rakakura seyepakati yemishonga uye reagent yekuchenesa yepamusoro-yekupedzisira zviridzwa.

Iyo molecular chimiro cheEribulin ine 19 chiral centers, uye synthesis matanho akareba sematanho makumi matanhatu nemaviri.Kusvika parizvino, Eribulin ichiri kutariswa neindasitiri seyakaomesesa isiri-peptide mushonga unogadzirwa neakachena kemikari synthesis, uye inogona kunzi Mount Everest muindasitiri yemakemikari synthesis.
Rondedzero yakabudirira yeEribulin inoratidza hurefu hutsva hunogona kuwanikwa nemakambani emishonga mukugadzirwa kwemakemikari nekugadzirwa kwemaindasitiri.Inounzawo mamwe mazano ekuongororwa uye ekurapa uye sarudzo kune varapi veChinese.Zvinotarisirwa kuti mune ramangwana rekiriniki maitiro, mushonga mutsva wechemotherapeutic Eribulin unogona kuunza tariro itsva kune varwere vegomarara rezamu.