Nicotinamide Riboside Cas: 1341-23-7
| Catalog Number | XD91951 |
| Product Name | Nicotinamide Riboside |
| CAS | 1341-23-7 |
| Molecular Formula | C11H15N2O5+ |
| Molecular Weight | 255.25 |
| Storage Details | Ambient |
| Harmonised Tariff Code | 2933199090 |
Chigadzirwa Specification
| Chitarisiko | Upfu chena |
| Assay | 99% min |
Nicotinamide Riboside inogona kushandiswa mubiological kudzidza yejini circadian reprogramming transcriptome muchiropa yakaonekwa nzira dzemetabolism dzekuchembera mugonzo.Iyo inowedzerawo NAD + mucerebral cortex uye inoderedza kuderera kwekuziva mune transgenic mbeva modhi yechirwere cheAlzheimer.
Nicotinamide adenine dinucleotide (NAD+) icoenzyme yakakosha iyo, kana yakaderedzwa kuita NADH, inoshanda sechinhu chinoderedza kupa maerekitironi kune oxidative phosphorylation uye ATP synthesis mumitochondria.NAD+ icofactor yakakosha yema enzymes akadai se sirtuins, ADP-ribosyltransferases (ARTs), uye Poly [ADP-ribose] polymerases (PARPs) uye inogara ichidyiwa nema enzymes aya.Iyo NAD +/NADH reshiyo chinhu chakakosha cheiyo redox mamiriro esero.(Verdin 2015).Nekumwe kuverenga, NAD kana iyo yakabatana NADP inotora chikamu muchikamu chechina chese maitiro emagetsi (Opitz Heiland 2015).Kune akapatsanurwa makamuri eNAD + mune nucleus, mitochondria, uye cytoplasm (Verdin 2015).
Nicotinamide riboside (NR) inogona kushandurwa kuita NAD+ kuburikidza nenhanho yepakati iyo inoshandurwa kuita nicotinamide mononucleotide (NMN) neNR kinase (Nrk) uyezve kuNAD+ neNMNATs.NR inongowanikwa mune zvimwe zvekudya asi pahuwandu hwakaderera (semuenzaniso low micromolar range).Kare, NR yainetsa kuwana muhuwandu hwakacheneswa, asi nekuda kwekufambira mberi kwenzira dzekubatanidza (Yang 2007), kubva munaChikumi 2013, inotengeswa sechikafu chekuwedzera.
