Orlistat Cas: 96829-58-2
| Catalog Number | XD91190 |
| Product Name | Orlistat |
| CAS | 96829-58-2 |
| Molecular Formula | C29H53NO5 |
| Molecular Weight | 495.73 |
| Storage Details | 2 kusvika ku8 °C |
Chigadzirwa Specification
| Chitarisiko | Upfu chena |
| Assay | 99% |
Mutsva uremu-kurasikirwa uye lipid-kudzikisa mushonga: Orlistat rudzi rutsva rwehuremu-kurasikirwa uye lipid-kudzikisa mushonga parizvino unozivikanwa pasi rese.Nekutengesa kwepagore kweUS $ 538 miriyoni, orlistat parizvino inotora 80% yepasi rose uremu musika, uye kutengeswa kwegore kuHong Kong, China chete inosvika US $80 miriyoni.Parizvino ndiyo yega OTC yekurasikirwa nemishonga munyika.Vanhu vanodarika 40 000 000 pasi rose vakaitora uye vakabudirira kuderedza uremu.Parizvino ndiyo inonyanya kutengesa uremu chigadzirwa.Inoshanda pakuderedza uremu.Orlistat ine simba uye yakareba-inobata chaiyo gastrointestinal lipase inhibitor.Nekuvhara zvakananga kutorwa kwemuviri kwemafuta muchikafu, kana kudyiwa kwekoriori nemafuta kuri kushoma pane kudyiwa, Mafuta emuviri anodzikiswa, kuitira kuti uwane chinangwa chekurasikirwa.Zvakachengeteka kuti uremerwe uremu, izvo zvinoshanda zvinoshandiswa hazvipindi mukutenderera kweropa, uye hazviiti panheyo yepakati.
Orlistat inogara kwenguva refu uye ine simba chaiyo gastrointestinal lipase inhibitor, chena kana isina-chena poda pamhepo tembiricha, isinganyungudika mumvura, inonyungudika mu chloroform, uye inonyungudika nyore mu ethanol.Iyo inoshanda serine nzvimbo dzegastric lipase uye pancreatic lipase inoumba covalent zvisungo kuti isaite ma enzymes.Mafuta ari muchikafu haagone kuderedzwa kuita emahara fatty acids uye monoacylglycerols, saka mafuta haagone kutorwa uye kushandiswa, nekudaro kuderedza kudyiwa kwekoriori yemuviri nekudzora uremu hwemuviri.Mushonga uyu haudi kuti systemic absorption ishande.Pamadhosi akajairika, kunyura kwemafuta kunogona kudziviswa ne30%.Iyo haiwanzo kubatwa mushure mekutonga kwemuromo, uye inogona kuvharwa nemetabolism mumatumbo emukati.Iyo metabolic saiti iri mumadziro egastrointestinal turakiti, uye kubviswa kwehafu yehupenyu inenge maawa gumi nemana kusvika gumi nemapfumbamwe.Inenge 97% yechigadzirwa ichi yakasvibiswa netsvina, iyo 83% inobudiswa mumhando yayo yepakutanga.
Inogona kushandiswa kiriniki mukufutisa uye hyperlipidemia.Mumamiriro ezvinhu akajairika, chiyero che 120 mg chinogona kutorwa nemuromo, katatu pazuva, nekudya kana 1 awa mushure mekudya.Huremu hunogona kutanga kudonha mushure memavhiki maviri ekutora mushonga.Inogona kutorwa nguva dzose kwemwedzi mitanhatu kusvika ku12.Kana iyo dose yakawedzerwa kusvika kune 400 mg pazuva, iyo mhedzisiro haichazowedzerwa.
