Platinum pane activated carbon Cas:7440-06-4
| Catalog Number | XD90696 |
| Product Name | Platinum pane activated carbon |
| CAS | 7440-06-4 |
| Molecular Formula | Pt |
| Molecular Weight | 195.08 |
| Storage Details | 2-8°C |
| Harmonised Tariff Code | 28439000 |
Chigadzirwa Specification
| Chitarisiko | silvery-grey meta |
| Assay | 99% |
| Dennity | 21.45 |
| Melting point | 1772℃ |
| Boiling point | 3827℃ |
| Refractive Index | n20/D 1.347 |
| Flash point | 3825°C |
| Mhepo pressure | 0 mm Hg (inenge) (NIOSH, 2016) |
Kuti uongorore riini platinamu-yakavakirwa anticancer agents akasiyana nechimiro uye nekudyidzana modhi yechinyakare cisplatin nekugadzira iyo bifunctional intrastrand 1,2 GpG adduct, iyo monofunctional platinum+ DNA adducts ine yakakura isina-covalent kudyidzana kwakadzidzwa.Izvo zvakashumwa kuti monofunctional testosterone-based platinum (II) vamiririri vanopa yakakwira anticancer chiitiko.Uyezve, zvakawanikwawo kuti testosterone-based platinum agents inogona kuita kuti DNA helix iite kusununguka uye kukotama pamusoro peasiri-testosterone-based platinum agents.Nekudaro, nzira dzekudyidzana dzeaya eplatinum agents ane DNA paatomic level haisati yanyatsojeka kusvika parizvino.Mubasa razvino, takashandisa ma molecular dynamics (MD) simulations uye DNA conformational dynamics calculations kuti tidzidze DNA distortion properties ye testosterone- based platinum + DNA, iyo yakagadziridzwa testosterone-based platinum + DNA uye iyo isiri testosterone-based platinum + DNA adducts.Mhedzisiro yacho inoratidza kuti kupindirana kwekudyidzana kweiyo yakagadziridzwa testosterone-based platinum agent ine DNA molecule inogona kukonzera yakakura DNA conformational kukanganisa kupfuura kupindirana-kwechiso kweiyo yakaoma testosterone-based platinum agent ine DNA molecule.Kumwe kuferefeta kweiyo isiri testosterone-based platinum agent inoratidza kuitika kwekuchinja kusingakoshi kweDNA conformation nekuda kwekushaikwa kwe testosterone ligand mumiririri akadaro.Kubva pane DNA dynamics analysis, DNA base motions ine chokuita neDNA groove parameter shanduko uye hydrogen bond kuparadzwa kweDNA base pairs zvakakurukurwawo mubasa iri.The flexible linker mune yakagadziridzwa testosterone-based platinum agent inokonzera kupindirana kwepakati neDNA mu. iyo yakagadziridzwa testosterone-based platinum + DNA adduct, iyo yakasiyana ne groove-face interaction inokonzerwa neakasimba linker mu testosterone-based platinum agent.Ongororo yemazuva ano inopa ruzivo runobatsira rweDNA conformation yakakanganiswa ne testosterone-based platinum complex paatomu.
