Polymyxin B sulfate CAS: 1405-20-5 White powder
| Catalog Number | XD90360 |
| Product Name | Polymyxin B sulfate |
| CAS | 1405-20-5 |
| Molecular Formula | C55H96N16O13 · 2H2SO4 |
| Molecular Weight | 1385.61 |
| Storage Details | 2 kusvika ku8 °C |
| Harmonised Tariff Code | 29419000 |
Chigadzirwa Specification
| Mhedziso | Inoenderana neUSP35 |
| Heavy metals | <20ppm |
| pH | 5-7 |
| Identification | Liquid chromatography: inoenderana |
| Assay | 99% |
| Chitarisiko | Upfu chena |
| Kurasika paKuomesa | <6% |
| Solubility | Yakasununguka soluble mumvura, zvishoma soluble muEthanol |
| Sulfate | 15.5% - 17.5% |
| Particle Size | <30µm |
| Specific optical rotation | -78° -90° |
| Phenylalanine | 9.0%-12.0% |
| Pyrogens | Inosangana nezvinodiwa |
| Sulfated ash | <0.75% |
| Yese inoshanda aerobic kuverenga | <100cfu/g |
| Potency | >6500 IU/mg |
Iyo ExPortal protein secretion organelle muStreptococcus pyogenes is an anionic phospholipid-ine membrane microdomain yakafumiswa muSec translocons uye postsecretion protein biogenesis factor.Polymyxin B inosungirira uye kukanganisa ExPortal kutendeseka, zvichikonzera kuvharika kwehupfu hwehupfu hwakati wandei.Kuti uwane nzwisiso yezvinhu zvinopesvedzera sangano reExPortal, chidzitiro chemajini chakaitwa kuti chisarudze chepolymyxin B-resistant mutants ichiratidza kuvimbika kweExPortal.Whole-genome resequencing ye25 resistant mutants yakaburitswa kubva kuimwe kusvika kuina shanduko pa genome inoshanduka yakaunganidzwa mukati mepakati peseti yemapoka gumi emajini.Kuvakwa kwemachinjiki nekudzimwa kwega kana kuiswa kwakaratidza kuti 7 core genes inopa kuramba uye inosimudzira ExPortal kuperera kuburikidza nekurasikirwa nebasa, nepo 3 ingangove nekuda kwekuwana basa uye / kana combinatorial mhedzisiro.Core resistance majini anosanganisira transcriptional regulator ye lipid biosynthesis, majini akati wandei anosanganisirwa mukutora chikafu chinovaka muviri, uye akasiyana emajini anobatanidzwa mukupindura kwekushushikana.Nhengo mbiri dzekirasi yekupedzisira dzinoshandawo seanova vatongi veyakavanzika SpeB cysteine protease.Ongororo yeanowanzo akasarudzika mutation, imwechete nucleotide deletion munzira ye9 inoteedzana adenine residues mu pstS, encoding chikamu chepamusoro-affinity Pi transporter, inoratidza kuti kutevedzana uku kunoshanda senge molecular switch kuti ifambise kunetseka kugadzirisa.Pamwe chete, idzi data dzinoratidza kuvepo kwe membrane stress mhinduro inosimudzira yakawedzera ExPortal kutendeseka uye kuramba kune cationic antimicrobial peptides.
