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R-PMPA, inozivikanwawo se tenofovir disoproxil fumarate (TDF), mushonga unorwisa mavhairasi unonyanya kushandiswa mukurapa hutachiona hwehuman immunodeficiency virus (HIV) uye hutachiona hwehepatitis B (HBV).Ichi chigadzirwa chemuromo chinoshandurwa kuita chimiro chayo, tenofovir diphosphate, mukati memuviri.R-PMPA ndeyeboka remishonga inonzi nucleotide reverse transcriptase inhibitors (NRTIs).Inoshanda nekudzivisa reverse transcriptase enzyme, iyo yakakosha pakudzokorora kweHIV neHBV.Nekuvhara danho rakakosha iri mukudzokororwa kwehutachiona, R-PMPA inobatsira kuderedza huwandu hwehutachiwana uye kunonoka kufambira mberi kwezvirwere. Kana inoshandiswa mukurapa HIV, R-PMPA inowanzotaurwa sechikamu chemusanganiswa weantiretroviral therapy. (cART) chirongwa.Inopihwa pamwe nemamwe maantiretroviral mishonga kubva kumakirasi akasiyana emishonga kuti iwedzere kushanda uye kuderedza kukura kwekusagadzikana kwemishonga.Iyo chaiyo yeCarT regimen ichaenderana nemurwere wega wega zvinhu, senge danho rehutachiona hweHIV, nhoroondo yekurapa yapfuura, uye chero mamiriro ehutano anoenderana.Mukurapa kwechirwere cheHBV chisingaperi, R-PMPA inowanzo kurongedzerwa se monotherapy kana kusanganiswa ne mamwe antiviral mishonga.Nguva yekurapa inogona kusiyana zvichienderana nekuoma kwehutachiona uye mhinduro yemunhu kumushonga.Muyero weR-PMPA uchatarwa nenyanzvi yehutano zvichienderana nezvinhu zvakadai sekushanda kwerenal, makore, uremu, uye kuvapo kwepi zvayo. mamwe mamiriro ekurapa.Zvakakosha kutevera mirairo yedosing uye kusagadzirisa chiyero pasina kubvunza mupi wehutano.R-PMPA inowanzobvumirwa zvakanaka, asi semishonga chero ipi zvayo, inogona kukonzera migumisiro.Zvinowanzoitika zvinosanganisira kuda kurutsa, kurutsa, manyoka, uye musoro.Mune zvimwe zviitiko, R-PMPA inogona kukonzera zvakakomba mhedzisiro, senge itsvo dysfunction kana bone mineral density kurasikirwa.Kugara uchitarisa kushanda kwetsvo uye hutano hwemapfupa zvinokurudzirwa panguva yekurapwa. Zvakakosha kutora R-PMPA sezvakarongerwa uye kutevedzera chirongwa chekurapa nguva dzose.Kusatora mapiritsi kana kumisa kurapwa nguva isati yakwana kunogona kukonzera kukura kwekuramba zvinodhaka uye kuderedza kushanda kwekurapa.Muchidimbu, R-PMPA (tenofovir disoproxil fumarate) mushonga unorwisa mavhairasi unoshandiswa mukurapa utachiona hweHIV uye hutachiwana hweHBV husingaperi.Inoshanda nekudzivisa hutachiona hwekudzokorora maitiro uye inowanzoshandiswa sechikamu chemusanganiswa wemishonga yeHIV.Kunyatsotarisa uye kutevedzera kurapwa kwakakosha kuti zvive nemigumisiro yakanaka.Kuonana nenyanzvi yezvehutano kwakakosha kuti uone chirongwa chakakodzera chekurapa uye kugadzirisa chero zvingangoitika.