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Rosuvastatin Intermediates ZD9, inozivikanwawo seZ-4-(4-Fluorophenyl) -6-Isopropyl-2-[(N-Methyl-N-Methylsulfonyl)Amino]Pyrimidin-5-Yl, ikemikari yemakemikari inoshanda sechinhu chinokosha. yepakati mukugadzirwa kweiyo cholesterol-inoderedza mushonga Rosuvastatin.Iyi yepakati inoita basa rakakosha mukugadzirwa kweRosuvastatin, inova yekirasi yemishonga inozivikanwa se statins.ZD9 inoshanda semushonga weprecursor mumubatanidzwa wematanho akawanda eRosuvastatin.Munguva yekugadzira, ZD9 inosangana nekuchinja kwakasiyana siyana kwemakemikari kuti pakupedzisira igoburitsa chigadzirwa chekupedzisira, Rosuvastatin.Iyi synthesis inosanganisira kusungirirwa kwemamwe mapoka anoshanda paZD9 molecule, zvichiita kuti pave nekugadzirwa kwemishonga inoshandiswa yemishonga, Rosuvastatin.Rosuvastatin inoshandiswa zvakanyanya pakurapa hypercholesterolemia, chimiro chinoratidzwa nehuwandu hwecholesterol muropa.Inoshanda nekudzivisa enzyme HMG-CoA reductase, iyo inoita basa rakakosha mukuumbwa kwecholesterol mumuviri.Nokuderedza kugadzirwa kwecholesterol, Rosuvastatin inobatsira kuderedza huwandu hwecholesterol, kusanganisira yakaderera-density lipoprotein (LDL) cholesterol, inowanzonzi "yakaipa" cholesterol.Sechikamu chepakati, ZD9 inovimbisa kuti kuumbwa kweRosuvastatin kunowedzera mune inodzorwa. uye nzira inoshanda.Inoshanda sechivakwa chekuvaka chinosangana nemaitiro emakemikari ekugadzirisa, zvichiita kuti pave nekuumbwa kwezvisungo zvakananga uye mapoka ekushanda anodiwa kune Rosuvastatin's pharmacological activity.The synthesis yeRosuvastatin inzira yakaoma, uye imwe neimwe yepakati, kusanganisira ZD9, inokosha mukuona. kuumbwa kwakakodzera kwechigadzirwa chekupedzisira.Pasina ZD9, kuumbwa kweRosuvastatin kwaisazogoneka, zvichitadzisa kugadzirwa kweiyi yakakosha cholesterol-inoderedza mishonga.Muchidimbu, Rosuvastatin Intermediates ZD9 inoshanda seyakakosha yepakati mukugadzirwa kweiyo inonyanya kushandiswa cholesterol-kudzikisa mishonga, Rosuvastatin.Inoshanda sechivakwa chekuvaka chinopinda makemikari shanduko kuti pakupedzisira ibudise inoshanda inoshanda mishonga yemishonga.Nekuita basa rakakosha mukugadzira, ZD9 inobatsira pakuwanikwa kwemushonga unokosha wekurapa kwepamusoro cholesterol muvarwere.