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(S)-(2-Chloro-5-iodophenyl)(4-(tetrahydrofuran-3-yloxy)phenyl)methanone, inozivikanwawo seCF3-112, ikemikari inosanganiswa neakawanda akakosha maapplication mumunda wekemesitiri yemishonga nemishonga. budiriro.Imwe yekushandiswa kukuru kweCF3-112 ndeye kinase inhibitor.Kinase ma enzymes anogadzirisa akasiyana siyana masero mumuviri, kusanganisira kukura kwesero, kupatsanura, uye kutaurirana.Dysregulation ye kinases inowanzobatanidzwa nezvirwere zvakaita segomarara uye autoimmune kusagadzikana.CF3-112 yakawanikwa ichiratidza zvine simba inhibitory chiitiko ichipokana nemamwe kinase, zvichiita kuti ive mumiriri anovimbisa mukuvandudza marapirwo anonangwa. anowanzo kuwedzererwa mumasero egomarara.Nekunyatsotarisa nekudzivisa aya kinase, CF3-112 inogona kubatsira kumisa kukurumidza kupararira kwemasero emukenza uye inogona kupa rubatsiro rwekurapa.Uyezve, CF3-112 yakaratidza basa rinopesana nemamwe kinase akadai seFLT3 neJAK2, ayo akabatanidzwa muhematological. zvirwere zvakadai seacute myeloid leukemia (AML) uye myeloproliferative neoplasms.Kuvharisa aya kinase neCF3-112 kune mukana wekukanganisa nzira dzechiratidzo dzinotyaira kukura uye kurarama kwemasero egomarara, zvichipa mikana mitsva yekurapa kwezvirwere izvi. Pamusoro pekuita kwayo kinase inhibitory, CF3-112 inogonawo kuva neanti -kuzvimba migumisiro.Inflammation ndeye yakaoma biological mhinduro inoita basa muzvirwere zvakawanda, zvinosanganisira autoimmune kusagadzikana uye kusingaperi kuzvimba mamiriro.CF3-112 yakaratidza kuvimbiswa se inhibitor yeimwe nzira dzekuputika, inogona kupa nzira yekurapa yekugadzirisa mamiriro aya.Kunyange zvazvo CF3-112 iine simba guru, zvakakosha kuziva kuti imwe tsvakurudzo nekuvandudzwa kunodiwa kuti unzwisise zvizere kushanda kwayo, kuchengeteka. profile, uye yakakwana application.Sezvinoita chero komisheni, kuongororwa kwakasimba uye zvidzidzo zvepreclinical zvinodikanwa zvisati zvakwanisa kufambira mberi kune miedzo yekiriniki yevanhu.Pakupedzisira, CF3-112 isanganiswa ine simba rakakosha mumunda wekemikari yemishonga.Yayo kinase inhibitory chiitiko, kunyanya ichipesana neAurora kinases, FLT3, uye JAK2, inoiisa seanogoneka mukana wekuvandudza marapirwo anonangwa ekenza uye hematological malignancies.Yayo inorwisa-kuzvimba zvimiro zvakare inoratidza zvingangoita maapplication mukugadzirisa autoimmune kusagadzikana uye kusingaperi kuzvimba mamiriro.Nekudaro, kumwe kutsvagisa kwakakosha kuvhura kugona kwayo kwekurapa kwakazara uye kuongorora kuchengetedzeka kwayo uye kushanda kwayo.