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Multitarget makomisheni ari kuwedzera kuteverwa pakurapa kunoshanda kwezvirwere zvakaomarara.Muno, tinotsanangura dhizaini uye magadzirirwo ekirasi nyowani yeshogaol-huprine mahybrids, anonzi akarova akati wandei akakosha zvinangwa zvine chekuita nechirwere cheAlzheimer.Iwo mahybrids akaedzwa mu vitro nekuda kwekuita kwavo kwekudzivirira kurwisa vanhu acetylcholinesterase uye butyrylcholinesterase uye antioxidant basa (ABTS +, DPPH uye Folin-Ciocalteu assays), uye mune intact Escherichia coli masero eAβ42 uye tau anti-aggregating basa.Zvakare, kupinda kwavo kwehuropi kwakaongororwa (PAMPA-BBB assay).Kunyange zvazvo mahybrids asina simba AChE inhibitors kana antioxidant agents semubereki huprine Y uye [4] -shogaol, zvichienderana, achiri kuratidza anticholinesterase ane simba uye antioxidant mabasa uye ane simba zvikuru Aβ42 uye tau anti-aggregating agents kupfuura mishonga yevabereki.Pakazere, iyo shogaol-huprine mahybrids anobuda seanonakidza uropi permeable multitarget anti-Alzheimer inotungamira.

Zvidimbu zveakasiyana polarity akawanikwa kubva kune dzakasiyana siyana zvirimwa (mudzi, shizha, ruva uye muchero) weSeseli rigidum zvakadzidzwa neakasiyana maantioxidant assays: DPPH uye ABTS radical scavenging chiitiko, nekuderedza kuzere nzira yemagetsi pamwe neyakakwana zvirimo zveflavonoids uye polyphenols. .Mafuta akakosha ezvikamu zvese zvezvirimwa airatidza hunhu husina simba hwe antioxidant.Iyo inhibitory concentration yezvinyorwa zvakaedzwa, kurwisa mabhakitiriya Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Bacillus cereus, uye fungi Candida albicans uye Aspergillus niger yaive 0.01-1.50 mg/mL uye ye microbicidal 0.0 mg/mL0.Mukudyidzana necholinesterase, mafuta ese akakosha airatidza kuti anoshanda se inhibitors.Iyo yepamusoro muzana yekudzivisa kunopesana nevanhu uye bhiza cholinesterase yakaratidzwa nemudzi akakosha mafuta (38.20% uye 48.30%, zvichiteerana) pakati pemafuta, uye midzi hexane extract (40.56% uye 50.65% zvichiteerana).Mafuta anokosha uye zvinhu zvinoputika zvezvikamu zvese zvezvirimwa zvakaonekwa neGC, GC-MS uye headspace/GC-MS.Statistical ongororo yekubatanidzwa kwemhedzisiro yakaratidza kuti mudzi wakakosha mafuta kuumbwa wakasiyana zvakanyanya kubva kumafuta akakosha ezvimwe zvikamu zvechirimwa.Tichifunga nezve zvese zvakadzidzwa zviitiko, iyo mudzi hexane inobvisa yakaratidza zvakanakisa zvivakwa zvese.Kuburikidza nepamusoro pekuita kwemvura chromatography yakasanganiswa nepamusoro-resolusheni mass spectrometry, makumi matatu ematunhu akanyanya kuwanda akaonekwa mune zvakatorwa zvakasiyana polarity.Kuvapo kwezvikamu zvakaonekwa kwakabatana nekucherechedzwa kwezviitiko zvebhayoloji, nekudaro kutara makomisheni anogona kuita basa reumwe neumwe anoratidzwa.