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Sitagliptin mushonga uri wekirasi yemishonga inonzi dipeptidyl peptidase-4 (DPP-4) inhibitors.Inonyanya kushandiswa mukutonga kwechirwere cheshuga mellitus.Chirwere cheshuga chinoitika kana muviri usingakwanise kunyatso gadzirisa mazinga eshuga yeropa, zvichitungamira kune yakakwira glucose muropa.Sitagliptin inoshanda nekuvharira iyo DPP-4 enzyme, iyo inokonzeresa kuputsa incretin hormone.Aya mahomoni anowedzera insulin secretion uye anoderedza kugadzirwa kweglucagon, zvinozotungamira kune yakawedzera kudzora mazinga eshuga yeropa.Nekuvharira iyo DPP-4 enzyme, sitagliptin inobvumira iyo incretin mahomoni kuti arambe achishanda kwenguva yakareba, nekudaro achivandudza kudzora shuga yeropa. Iyo yekutanga nzira yekutonga yesitagliptin ndeyemuromo, uye inogona kutorwa nekudya kana pasina.Muyero wakatarwa nenyanzvi yehutano unoenderana nemurwere wega wega, sekuoma kwechirwere cheshuga nemimwe mishonga iri kushandiswa.Zvakakosha kutevera mirairo yedosing zvakanyatsonaka uye kusagadzirisa chiyero pasina kubvunzurudza mupi wehutano.Sitagliptin inowanzoshandiswa sechinhu chinogadzirisa kudya uye kurovedza muviri mukutarisira kwechirwere cheshuga mellitus.Inonyanya kunyorerwa pamwe chete nekuchinja kwemararamiro uye mimwe mishonga yeantidiabetic, senge metformin.Nekubatanidza nzira dzakasiyana dzekuita, dzakadai sesitagliptin's DPP-4 inhibition uye metformin yekuvandudza insulin senitivity, zviri nani glycemic control inogona kuwanikwa.Kushanda kwesitagliptin mukudzora mazinga eshuga yeropa kwakaratidzwa mune dzakawanda miedzo yekiriniki.Zvidzidzo zvakaratidza kuti inogona kuderedza zvose kutsanya uye postprandial (mushure mekudya) mazinga eglucose, kuderedza glycated hemoglobin (HbA1c) mazinga, uye kunatsiridza glycemic control yakazara. sekutemwa nemusoro, chepamusoro kufema turakiti zvirwere, uye gastrointestinal kuvhiringidzika kufanana kuda kurutsa kana manyoka.Sezvinoita chero mushonga, kusawirirana kwakakomba uye zvisingawanzo asi zvakakomba zvinokonzeresa zvinogona kuitika, saka zvakakosha kuzivisa chero zviratidzo zvisina kujairika kana zvakakomba kunyanzvi yezvehutano nekukasika. .SeDPP-4 inhibitor, inobatsira kuvandudza glycemic control nekuwedzera basa reincretin hormone.Kana ikashandiswa pamwe chete nemararamiro ekuchinja uye mamwe mishonga yeantidiabetic, sitagliptin inogona kuva chishandiso chinoshanda mukudzora mazinga eshuga yeropa uye kubata chirwere cheshuga chechipiri.Kunyatsotarisisa uye kubvunzana nemupi wehutano kwakakosha kuti uwane mhedzisiro.