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L-Ascorbic Acid, Calcium Ascorbate, Magnesium Ascorbate, Magnesium Ascorbyl Phosphate, Sodium Ascorbate, uye Sodium Ascorbyl Phosphate basa mukuumbwa kwezvizoro zvakanyanya se antioxidants.Ascorbic Acid inowanzonzi Vitamin C. Ascorbic Acid inoshandiswa seantioxidant uye pH inogadzirisa mune zvakasiyana-siyana zvekushongedza zvizoro, pamusoro pe3 / 4 iyo yaiva dhayi dzebvudzi uye mavara pahuwandu huri pakati pe0.3% ne0.6%.Kune mamwe mashandisirwo, iyo yakashumwa yakawedzera yakaderera (<0.01%) kana mu5% kusvika 10%.Calcium Ascorbate uye Magnesium Ascorbate zvinotsanangurwa se antioxidants uye ganda conditioning agents - zvakasiyana-siyana zvekushandisa muzvizoro, asi hazvisati zvave kushandiswa.Sodium Ascorbyl Phosphate inoshanda seantioxidant muzvigadzirwa zvekuzora uye inoshandiswa pazvikamu zvinotangira pa0.01% kusvika 3%.Magnesium Ascorbyl Phosphate inoshanda seantioxidant muzvizoro uye yakanzi iri kushandiswa pakudzika kubva pa0.001% kusvika 3%.Sodium Ascorbate inoshandawo seantioxidant muzvizoro pazvikamu kubva pa0.0003% kusvika 0.3%.Zvinoenderana zvinongedzo (Ascorbyl Palmitate, Ascorbyl Dipalmitate, Ascorbyl Stearate, Erythorbic Acid, uye Sodium Erythorbate) zvakamboongororwa neCosmetic Ingredient Ongororo (CIR) Nyanzvi Panel uye yakawanikwa "yakachengeteka kushandiswa sezvizoro zvezvizoro mumaitiro aripo ezvakanaka. kushandisa."Ascorbic Acid inowanzo zivikanwa seyakachengeteka (GRAS) chinhu chekushandisa sechemikari inochengetedza muzvikafu uye sechikafu uye / kana chikafu chekuwedzera.Calcium Ascorbate uye Sodium Ascorbate zvakanyorwa se GRAS zvinhu zvekushandisa semakemikari anochengetedza.L-Ascorbic Acid iri nyore uye inodzoreredzwa oxidized kuL-dehydroascorbic acid uye mafomu ese ari maviri aripo mukuenzana mumuviri.Permeation rates yeAscorbic Acid kuburikidza neganda rose uye rakabviswa mbeva yaive 3.43 +/- 0.74 microg/cm(2)/h uye 33.2 +/- 5.2 microg/cm(2)/h.Zvidzidzo zvepamuromo uye zvevabereki mumakonzo, makonzo, tsuro, guinea pigs, imbwa, uye katsi zvakaratidza huturu hudiki.Ascorbic Acid uye Sodium Ascorbate yakashanda se nitrosation inhibitor mune akati wandei chikafu uye cosmetic chigadzirwa zvidzidzo.Hapana zviratidzo zvekiriniki zvine hukama kana gross kana microscopic pathological effects zvakaonekwa mune mbeva, makonzo, kana guinea pigs muzvidzidzo zvenguva pfupi.Male guinea pigs akadyisa control basal diet uye akapiwa kusvika ku250 mg Ascorbic Acid nemuromo kwemavhiki makumi maviri aiva nehemoglobin yakafanana, glucose yeropa, serum iron, chiropa chechiropa, uye chiropa cheglycogen mazinga akaenzaniswa nemaitiro ekutonga.Makonzo echirume neechikadzi F344/N uye B6C3F (1) mbeva dzakadyiswa kudya kunosvika ku100,000 ppm Ascorbic Acid kwemavhiki e13 nehuturu hudiki.Chronic Ascorbic Acid yekudyisa zvidzidzo zvakaratidza muchetura pamiyero iri pamusoro pe25 mg/kg uremu hwemuviri (bw) mumakonzo nenguruve.Mapoka emakonzo echirume neechikadzi aipihwa madosi ezuva nezuva anosvika 2000 mg/kg bw Ascorbic Acid kwemakore maviri akanga asina macro- kana microscopically detectable chepfu maronda.Mice dzakapiwa Ascorbic Acid subcutaneous uye intravenous daily doses (500 kusvika 1000 mg / kg bw) kwemazuva 7 akanga asina kuchinja mukuda kudya, kuwedzera uremu, uye maitiro ose;uye histological kuongorora nhengo dzakasiyana-siyana akaratidza hapana kuchinja.Ascorbic Acid yaive photoprotectant payakaiswa kune mbeva neganda renguruve isati yasangana nemirairo ye ultraviolet (UV).Iyo inhibition yeUV-induced kudzvanywa kwekubata hypersensitivity kwakacherechedzwa zvakare.Magnesium Ascorbyl Phosphate manejimendi pakarepo mushure mekuratidzwa mumakonzo asina vhudzi zvakanyanya kunonoka kuumbwa kwebundu reganda uye hyperplasia inokonzerwa nekusingaperi kuratidzwa kune UV mwaranzi.Mbeva dzine pamuviri nemakonzo zvakapiwa zuva nezuva oral doses yeAscorbic Acid kusvika ku1000 mg / kg bw pasina zviratidzo zvevakuru-chepfu, teratogenic, kana fetotoxic madhara.Ascorbic Acid uye Sodium Ascorbate yakanga isiri genotoxic mune akati wandei mabhakitiriya uye mammalian bvunzo masisitimu, anoenderana neiyo antioxidant zvimiro zvemakemikari aya.Muhupo hwemamwe ma enzyme masisitimu kana simbi ions, humbowo hwegenotoxicity hwakaonekwa.National Toxicology Program (NTP) yakaita 2-year oral carcinogenesis bioassay yeAscorbic Acid (25,000 uye 50,000 ppm) muF344/N makonzo uye B6C3F (1) mbeva.Ascorbic Acid yakanga isiri carcinogenic mune chero yebonde yemakonzo nemakonzo.Kudzivirirwa kwecarcinogenesis uye bundu kukura zvine chekuita neAscorbic Acid's antioxidant properties yakataurwa.Sodium Ascorbate yakaratidzwa kusimudzira kusimudzira weti carcinomas mune maviri-nhanho carcinogenesis zvidzidzo.Dermal kushandiswa kweAscorbic Acid kune varwere vane radiation dermatitis uye vanopisa vakakuvadzwa hakuna mhedzisiro yakaipa.Ascorbic Acid yaive photoprotectant mumakiriniki emunhu UV zvidzidzo pamadosi zviri pamusoro peiyo shoma erythema dose (MED).Iro opaque ine 5% Ascorbic Acid haina kukurudzira dermal sensitization mu103 vanhu zvidzidzo.Chigadzirwa chine 10% Ascorbic Acid chaive chisiri irritant mune ye4-day minicumulative patch assay paganda remunhu uye kurapwa kwechiso kuine 10% Ascorbic Acid yakanga isiri yekubata sensitizer mune yekuwedzera assay pane 26 vanhu.Nekuda kwemaitiro uye anoshanda akafanana ezvisanganiswa izvi, iyo Panel inotenda kuti iyo data pane chimwe chinhu chinogona kuwedzeredzwa kune ese.Nyanzvi Panel yakataura zvakawanikwa kuti Ascorbic Acid yaive genotoxic mune mashoma aya masisitimu ekuyedza nekuda kwekuvapo kwemamwe makemikari, semuenzaniso, simbi, kana mamwe ma enzyme masisitimu, ayo anoshandura zvinobudirira Ascorbic Acid's antioxidant chiito kune icho chepro-oxidant.Kana Ascorbic Acid ichiita se antioxidant, iyo Panel yakagumisa kuti Ascorbic Acid haisi genotoxic.Kutsigira maonero aya kwaiva zvidzidzo zvecarcinogenicity zvakaitwa neNTP, izvo zvakaratidza pasina humbowo hwecarcinogenicity.Ascorbic Acid yakawanikwa ichinyatso kuvharidzira goho renitrosamine mune akati wandei ebvunzo masisitimu.Iyo Panel yakaongorora zvidzidzo umo Sodium Ascorbate yakashanda seanosimudzira bundu mumhuka.Mhedzisiro iyi yaionekwa seine hukama neiyo sodium ions uye pH yeweti mumhuka dzekuyedza.Migumisiro yakafanana yakaonekwa ne sodium bicarbonate.Nekuda kwekunetsekana kwekuti mamwe maion esimbi anogona kusanganiswa neizvi zvinongedzo kugadzira pro-oxidant chiitiko, iyo Panel yakayambira vanogadzira kuti vave nechokwadi chekuti zvinhu izvi zviri kuita sema antioxidants mukuumbwa kwecosmetic.Panel yaitenda kuti chiitiko chekiriniki umo ascorbic Acid yakashandiswa paganda rakakuvadzwa pasina mhedzisiro uye yekudzokorora-kutuka chigamba bvunzo (RIPT) uchishandisa 5% Ascorbic Acid ine mhedzisiro yakaipa inotsigira kuwanikwa kuti boka iri rezvinwiwa hariratidzi a. njodzi yekunzwa ganda.Idzi data pamwe chete nekusavapo kwemishumo mumabhuku ekiriniki eAscorbic Acid sensitization inotsigira zvakasimba kuchengetedzwa kwezvinhu izvi.