Spiramycin Cas: 8025-81-8
| Catalog Number | XD90452 |
| Product Name | Spiramycin |
| CAS | 8025-81-8 |
| Molecular Formula | C43H74N2O14 |
| Molecular Weight | 843.05 |
| Storage Details | 2 kusvika ku8 °C |
| Harmonised Tariff Code | 29419000 |
Chigadzirwa Specification
| Chitarisiko | White Powder |
| Assay | >4100IU/mg |
| Heavy metals | <20ppm |
| Kurasika paKuomesa | <3.5% |
| Sulfated Ash | <1.0% |
| Ethanol | <2.0% |
| Specific optical rotation | -85 kusvika -80 deg |
Streptomyces ambofaciens inogadzira macrolide antibiotic spiramycin.Iyo biosynthetic gene cluster ye spiramycin yakamisikidzwa kune S. ambofaciens.Pamusoro peiyo regulatory gene srmR (srm22), yakambozivikanwa (M. Geistlich et al., Mol. Microbiol. 6: 2019-2029, 1992), matatu putative regulatory genes akaonekwa nekutevedzana kwekuongorora.Gene expression analysis uye gene inactivation miedzo yakaratidza kuti imwe chete yemajini matatu aya, srm40, inobata basa guru mukugadzirisa spiramycin biosynthesis.Kuvhiringidzwa kwe srm22 kana srm40 kwakabvisa kugadzirwa kwe spiramycin ukuwo kuwedzeredza kwavo kwakawedzera kugadzirwa kwe spiramycin.Ongororo yekutaura yakaitwa nereverse transcription-PCR (RT-PCR) kune ese majini esumbu mune yesango-mhando strain uye mune srm22 (srmR) uye srm40 deletion mutants.Mhedzisiro kubva pakuongorora kwekutaura, pamwe chete neaya kubva mukuedzerwa kwekuwedzera, zvakaratidza kuti Srm22 inodiwa pakutaura kwe srm40, Srm40 iri nzira-chaiyo activator inodzora zvakanyanya, kana zvisiri zvese, zve spiramycin biosynthetic majini.
