Streptozocin CAS:18883-66-4 Pale yellow crystalline poda
| Catalog Number | XD90359 |
| Product Name | streptozocin |
| CAS | 18883-66-4 |
| Molecular Formula | C8H15N3O7 |
| Molecular Weight | 265.22 |
| Storage Details | -20 °C |
| Harmonised Tariff Code | 29419090 |
Chigadzirwa Specification
| Assay | 99% |
| Chitarisiko | Pale yellow crystalline powder |
Chirwere cheshuga mellitus chakabatana nekudzika-giredhi chisingaperi kuzvimba uye oxidative kusagadzikana.Bupleurum Polysaccharides (BPs), yakaparadzaniswa kubva kuBupleurum smithii var.parvifolium ine anti-inflammatory uye anti-oxidative properties.Zvisinei, zvishoma zvinozivikanwa pamusoro pemigumisiro yaro yekurapa pachirwere cheshuga.Mukuedza uku, mhedzisiro yeBPs pakuderedza chirwere cheshuga uye nzira dziri pasi dzakaongororwa.Diabetic mbeva modhi yakavambwa kuburikidza neanotevedzana intraperitoneal majekiseni e streptozotocin (100 mg/kg uremu hwemuviri) kwemazuva maviri.Mbeva dzine mazinga eglucose eropa akakwirira kupfuura 16.8mmol/L akasarudzwa kuti aedze.Iro mbeva dzeshuga dzakapiwa nemuromo neBPs (30 uye 60 mg / kg) kamwe chete pazuva kwemazuva 35.BP haina kungoderedza zvakanyanya mazinga eglucose yeropa, asiwo yakawedzera iyo ye serum insulin uye chiropa glycogen mumakonzo ane chirwere cheshuga zvichienzaniswa nemhando yemakonzo.Pamusoro pezvo, kutonga kweBPs kwakavandudza kutaura kwe insulin uye kudzvinyirira apoptosis mupancreas yemakonzo ane chirwere cheshuga.Histopathological yakaratidza zvakare kuti BPs yakadzivirira pancreas uye chiropa kubva mukukuvadzwa kweoxidative uye kuzvimba.Mhedzisiro iyi inoratidza kuti BP inodzivirira pancreatic β masero uye chiropa hepatocytes uye inameliorate chirwere cheshuga, icho chinosanganiswa neayo anti-oxidative uye anti-inflammatory properties.
