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Telithromycin yakatangwa kuGermany semushonga wemukanwa kamwe chete pazuva wezvirwere zvekufema zvinosanganisira mabayo anowanikwa munharaunda, acute bacteria exacerbations of chronic bronchitis, acute sinusitis uye tonsillitis/pharyngitis.Iyi semisynthetic inobva kune zvakasikwa macrolide erythromycin ndiyo yekutanga kutengeswa ketolide, kirasi itsva yemishonga inorwisa mabhakitiriya ine C3-ketone panzvimbo yeL-cladinose boka.Iyo 14-membered ring antibacterial agent inodzivirira bhakitiriya mapuroteni synthesis nekusunga kumatunhu maviri e50S subunit yemabhakitiriya ribosomes.Inoratidza zvine simba mu vitro chiitiko chinopesana neakajairika hutachiona hwekufema zvinosanganisira Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis uye Streptococcus pyogenes pamwe nemamwe hutachiona hweatypical.Iboka re3-keto rinopa kuwedzera kugadzikana kweasidhi uye kuderedza kuiswa kwe macrolide-lincosamide-streptogramin B kuramba iyo inowanzoonekwa ne macrolides.Iyo yakatsiviwa C11-C12 carbamate residue inoratidzika kwete chete kuwedzera hukama hweiyo ribosomal inosunga saiti asi zvakare kudzikamisa mukomboni kurwisa esterase hydrolysis uye kudzivirira kuramba nekuda kwekubviswa kwema macrolides kubva muchitokisi nepombi ye efflux yakavharidzirwa ne mef gene mune mamwe hutachiona. .Telithromycin zvose inhibitor yemakwikwi uye substrate yeCYP3A4.Zvisinei, kusiyana nemacrolides akawanda akadai troleandomycin, haigadziri kugadzikana inhibitory CYP P-450 Fe2 + -nitrosoalkane metabolite complex iyo inogona kuita hepatotoxic.Mushonga wacho unobvumirwa zvakanaka uye wakagovaniswa zvakanaka mumapapu, bronchial secretions, tonsils uye mate.Iyo inoshanduka kuve yakanyanya kunyura muazurophil granules yepolymorphonuclear neutrophils nekudaro kufambisa kuendesa kwayo kune phagocytosed mabhakitiriya.