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Tert-butyl 4-(6-((6-(1-butoxyvinyl)-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino) pyridin-3-yl)piperazine-1-carboxylate musanganiswa une simba guru mumakemikari emishonga uye kukura kwezvinodhaka.Yayo yakaoma molecular structure inoratidzira zvakasiyana-siyana zvinogona kushandiswa.Ichi chikwata chine piperazine-1-carboxylate core, iyo inowanzoshandiswa scaffold mumakemikari emishonga nekuda kwemaitiro ayo akasiyana-siyana uye zvakasiyana-siyana zvechinangwa chezvinodhaka zvingaita.Kuvapo kwepiperazine moiety inobvumira kupindirana nemhando dzakasiyana-siyana dzekugamuchira uye enzymes, zvichiita kuti ive mukana unofadza wekugadzirwa kwemishonga yekurapa.The 6-(1-butoxyvinyl) -8-cyclopentyl-5-methyl-7-oxo-7, 8-dihydropyrido [2,3-d] pyrimidin-2-yl boka muchimiro chinopa zvingangoita zvemishonga.Pyrido [2,3-d] pyrimidine derivatives yakadaro yakadzidzwa zvakanyanya kune yavo yekudzivirira-kuzvimba, antiviral, uye anticancer properties.Mapoka e-cyclopentyl uye methyl anobatsira pakuita lipophilicity yekomboni, iyo inogona kuwedzera kushandiswa kwayo kwemasero uye bioavailability.The tert-butyl ester boka rinopa kugadzikana kune imwe nzvimbo uye rinogona kuchinjwa nyore nyore kune mamwe mapoka anoshanda, zvichibvumira kuwedzera kuchinjwa kana kubviswa.Izvi zvinogadziriswa zvakakosha mumakemikari emishonga, sezvo zvichiita kuti kuve nekugadzirwa kwezvimwe zvine simba uye zvakasarudzwa.Iboka repyridin-3-yl muhutano hunoita sechigadziro chekugadzirisa zvakasiyana-siyana, zvakadai seG protein-coupled receptors (GPCRs).Izvi zvinoratidza kuti komisheni inogona kuva nemigumisiro panzira dzechiratidzo che intracellular uye inogona kuongororwa zvakare nekuda kwekugona kwayo se modulator kana muvengi wezvakagamuchirwa zvakagamuchirwa zvinobatanidzwa mumamiriro ezvirwere. (1-butoxyvinyl) -8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate zvakakwirira kugona kwayo mukugadzirwa kwenovel therapeutics.Inopa mikana yekuongorora enzyme inhibition, receptor binding, uye modulation yezvakasiyana biological process.Nekumwe kuongorora uye optimization, komisheni iyi inogona kushanda sechinhu chinotungamira mukugadzirwa kwemishonga inonangana nekenza, kuzvimba, kana zvimwe zvirwere.Hunhu hwayo hwakasiyana hwezvimiro uye zviitwa zvebhayoloji zvinogona kuita kuti ive chinhu chinonakidza chekuwedzera kutsvagisa nekusimudzira mumunda wekemikari yemishonga.Pakupedzisira, tert-butyl 4-(6-((6-(1-butoxyvinyl)-8-cyclopentyl-) 5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate inobata chivimbiso sechinhu chinoshandiswa zvakasiyana-siyana chekugadzirwa kwezvinodhaka.Chimiro chayo chakaomarara uye zvingangoita zvemishonga zviitiko zvinoita kuti ive inonakidza mukwikwidzi wekuenderera mberi nekuferefetwa seanogona kurapa mumiriri wezvirwere zvakasiyana uye mamiriro.