Products

Trans-1-(tert-Butoxycarbonyl) -4-(3-(trifluoromethyl)phenyl)pyrrolidine-3-carboxylic acid ikemikari isanganiswa ine zvakasiyana-siyana zvinogona kushandiswa mumunda we organic synthesis uye tsvakurudzo yemishonga.Inoratidzwa nekuvapo kwemhete yepyrrolidine inotsiviwa neboka re tert-butoxycarbonyl (Boc) rinodzivirira paatomu ye nitrogen uye boka re trifluoromethyl pa phenyl ring.Imwe yezvinonyanya kushandiswa trans-1-(tert-Butoxycarbonyl) - 4- (3- (trifluoromethyl) phenyl) pyrrolidine-3-carboxylic acid yakaita sepakati mukugadzirwa kwemamwe organic compounds.Chimiro chayo chakasiyana uye mapoka anoshanda anoita kuti ive chivako chakasiyana-siyana chekuvaka mamorekuru akaoma.Boka reBoc rinoshanda seboka rinodzivirira, iro rinogona kubviswa zvakasarudzika pasi pemamiriro ekuita kuti afumure saiti inoshanda kuti iwedzere kugadziridzwa.Izvi zvinobvumira kudzorwa uye kwakanyatsojeka shanduko yehupenyu.Iyo trifluoromethyl boka mu trans-1- (tert-Butoxycarbonyl) -4- (3- (trifluoromethyl) phenyl) pyrrolidine-3-carboxylic acid inopawo zvinhu zvakakosha uye zvinogona kushandiswa.Mapoka eTrifluoromethyl anozivikanwa nehunhu hwavo hwekubvisa maerekitironi uye lipophilicity, izvo zvinogona kuwedzera simba, metabolic kugadzikana, uye bioavailability yevanoda zvinodhaka.Uyezve, boka re trifluoromethyl rinogona kugadzirisa physicochemical properties yekomboni, inokanganisa solubility, lipophilicity, uye receptor inosunga hukama. carboxylic acid inogona kuratidza biological chiitiko pachayo kana seprodrug.Prodrugs ibiologically isingashande makomisheni ayo anochinja makemikari kana enzymatic mumuviri kuti ashandure kuita mishonga inoshanda.Mune zvimwe zviitiko, boka rekudzivirira reBoc rinogona kubviswa zvakasarudzwa mu vivo, richiita kuti komisheni iite kurapa kunodiwa.Kunyange zvazvo zvikumbiro uye zvingangoshandiswa zve trans-1-(tert-Butoxycarbonyl) -4-(3-(trifluoromethyl) phenyl)pyrrolidine-3-carboxylic acid yakawanda, kuenderera mberi nekuferefeta nekutsvagisa kunodiwa kuti uongorore kugona kwayo kuzere.Izvi zvinowanzo sanganisira yekurapa chemistry optimization, chimiro-chiitwa hukama hukama zvidzidzo, uye biological kuongororwa.Nekunyatsonzwisisa zvimiro zvekomboni uye reactivity, masayendisiti anogona kuongorora kukodzera kwayo kunangana nezvirwere kana mamiriro, zvichitungamira mukuvandudzwa kwevanoda zvinodhaka zvinodhaka kana catalytic agents mune ramangwana.